ID   E5RFU9_HUMAN            Unreviewed;       201 AA.
AC   E5RFU9;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Serine protease inhibitor Kazal-type 5 {ECO:0000313|Ensembl:ENSP00000427943};
GN   Name=SPINK5 {ECO:0000313|Ensembl:ENSP00000427943};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427943, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427943, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427943}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC006524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RFU9; -.
DR   SMR; E5RFU9; -.
DR   jPOST; E5RFU9; -.
DR   PeptideAtlas; E5RFU9; -.
DR   PRIDE; E5RFU9; -.
DR   Ensembl; ENST00000476697; ENSP00000427943; ENSG00000133710.
DR   UCSC; uc063iko.1; human.
DR   EuPathDB; HostDB:ENSG00000133710.15; -.
DR   HGNC; HGNC:15464; SPINK5.
DR   OpenTargets; ENSG00000133710; -.
DR   eggNOG; ENOG410IP0D; Eukaryota.
DR   eggNOG; ENOG4111TR7; LUCA.
DR   GeneTree; ENSGT00510000048608; -.
DR   ChiTaRS; SPINK5; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000133710; Expressed in 130 organ(s), highest expression level in mouth mucosa.
DR   ExpressionAtlas; E5RFU9; baseline and differential.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 2.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RFU9,
KW   ECO:0000213|PeptideAtlas:E5RFU9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    201       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196807.
FT   DOMAIN       91    153       Kazal-like.
FT                                {ECO:0000259|PROSITE:PS51465}.
SQ   SEQUENCE   201 AA;  22230 MW;  EEAA7A5242379391 CRC64;
     MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF FQSLDGIMFI
     NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF KKGERDGDFI CPDYYEAVCG
     TDGKTYDNRC ALCAENAKTG SQIGVKSEGE CKSSNPEQFC EPVMVGEGEG RKDLIHVTLV
     FFQEIGSKLM ARTVLCLSSG T
//