ID   E5RFR1_HUMAN            Unreviewed;       105 AA.
AC   E5RFR1;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   12-SEP-2018, entry version 47.
DE   SubName: Full=Proenkephalin-A {ECO:0000313|Ensembl:ENSP00000428012};
DE   Flags: Fragment;
GN   Name=PENK {ECO:0000313|Ensembl:ENSP00000428012};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428012, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428012, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428012}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU004400}.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000256|RuleBase:RU004400}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC023464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RFR1; -.
DR   PeptideAtlas; E5RFR1; -.
DR   PRIDE; E5RFR1; -.
DR   Ensembl; ENST00000518974; ENSP00000428012; ENSG00000181195.
DR   UCSC; uc064mzi.1; human.
DR   EuPathDB; HostDB:ENSG00000181195.10; -.
DR   HGNC; HGNC:8831; PENK.
DR   OpenTargets; ENSG00000181195; -.
DR   eggNOG; ENOG410IJUY; Eukaryota.
DR   eggNOG; ENOG4110ZYD; LUCA.
DR   GeneTree; ENSGT00530000063761; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000181195; Expressed in 187 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; E5RFR1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000703; Proenkphlin_A.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01029; PENKAPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU004400};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Neuropeptide {ECO:0000256|RuleBase:RU004400};
KW   Opioid peptide {ECO:0000256|RuleBase:RU004400};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E5RFR1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    105       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196806.
FT   NON_TER     105    105       {ECO:0000313|Ensembl:ENSP00000428012}.
SQ   SEQUENCE   105 AA;  11779 MW;  8C07304557E1A776 CRC64;
     MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM ECEGKLPSLK
     IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY GGFMK
//