ID   E5RFG2_HUMAN            Unreviewed;       522 AA.
AC   E5RFG2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 54.
DE   SubName: Full=Semaphorin-4G {ECO:0000313|Ensembl:ENSP00000428896};
DE   Flags: Fragment;
GN   Name=SEMA4G {ECO:0000313|Ensembl:ENSP00000428896};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428896, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428896, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428896}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AL133215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RFG2; -.
DR   MaxQB; E5RFG2; -.
DR   PeptideAtlas; E5RFG2; -.
DR   PRIDE; E5RFG2; -.
DR   Ensembl; ENST00000519649; ENSP00000428896; ENSG00000095539.
DR   UCSC; uc057vky.1; human.
DR   EuPathDB; HostDB:ENSG00000095539.15; -.
DR   HGNC; HGNC:10735; SEMA4G.
DR   OpenTargets; ENSG00000095539; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000157186; -.
DR   ChiTaRS; SEMA4G; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000095539; Expressed in 146 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; E5RFG2; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RFG2,
KW   ECO:0000213|PeptideAtlas:E5RFG2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    522       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198512.
FT   DOMAIN       35    505       Sema. {ECO:0000259|PROSITE:PS51004}.
FT   NON_TER     522    522       {ECO:0000313|Ensembl:ENSP00000428896}.
SQ   SEQUENCE   522 AA;  58416 MW;  87920CD9FCE9F6CD CRC64;
     MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK GQAQNYSTLL
     LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM QSKCHQKGKN NQTECFNHVR
     FLQRLNSTHL YACGTHAFQP LCAAIDAEAF TLPTSFEEGK EKCPYDPARG FTGLIIDGGL
     YTATRYEFRS IPDIRRSRHP HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY
     FFTERATEEG SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE
     TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG PYMEYQDGSR
     RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF VKLHPLMARP VVPTRGRPLL
     LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT ADGWIHKAVV LGSGMHIIEE TQVFRESQSV
     ENLVISLLQH SLYVGAPSGV IQLPLSSCSR YRSCYDCILA RD
//