ID   E5RFE2_HUMAN            Unreviewed;        95 AA.
AC   E5RFE2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 59.
DE   SubName: Full=Lysyl oxidase homolog 2 {ECO:0000313|Ensembl:ENSP00000428933};
DE   Flags: Fragment;
GN   Name=LOXL2 {ECO:0000313|Ensembl:ENSP00000428933};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428933, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428933, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428933}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC090197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RFE2; -.
DR   PeptideAtlas; E5RFE2; -.
DR   Ensembl; ENST00000519243; ENSP00000428933; ENSG00000134013.
DR   UCSC; uc064lex.1; human.
DR   EuPathDB; HostDB:ENSG00000134013.15; -.
DR   HGNC; HGNC:6666; LOXL2.
DR   OpenTargets; ENSG00000134013; -.
DR   eggNOG; ENOG410IE2X; Eukaryota.
DR   eggNOG; ENOG410XSN1; LUCA.
DR   GeneTree; ENSGT00940000155874; -.
DR   ChiTaRS; LOXL2; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000134013; Expressed in 180 organ(s), highest expression level in smooth muscle tissue.
DR   ExpressionAtlas; E5RFE2; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 1.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26     95       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413774.
FT   DOMAIN       58     95       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   NON_TER      95     95       {ECO:0000313|Ensembl:ENSP00000428933}.
SQ   SEQUENCE   95 AA;  10811 MW;  A91867FAB5D02742 CRC64;
     MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL
     AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHV
//