ID   PBMU2_HUMAN             Reviewed;         251 AA.
AC   E2RYF7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   RecName: Full=Protein PBMUCL2;
DE   AltName: Full=HLA complex group 22;
DE   AltName: Full=Panbronchiolitis-related mucin-like protein 2;
DE   Flags: Precursor;
GN   Name=HCG22; Synonyms=G2, PBMUCL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Lung;
RX   PubMed=20981447; DOI=10.1007/s00439-010-0906-4;
RA   Hijikata M., Matsushita I., Tanaka G., Tsuchiya T., Itoh H.,
RA   Tokunaga K., Ohashi J., Homma S., Kobashi Y., Taguchi Y., Azuma A.,
RA   Kudoh S., Keicho N.;
RT   "Molecular cloning of two novel mucin-like genes in the disease-
RT   susceptibility locus for diffuse panbronchiolitis.";
RL   Hum. Genet. 129:117-128(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in the brain, lung, spleen, thymus
CC       and prostate. {ECO:0000269|PubMed:20981447}.
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DR   EMBL; AB560771; BAJ24155.1; -; mRNA.
DR   EMBL; CR759772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001335178.1; NM_001348249.1.
DR   UniGene; Hs.207528; -.
DR   ProteinModelPortal; E2RYF7; -.
DR   SMR; E2RYF7; -.
DR   BioMuta; HGNC:27780; -.
DR   EPD; E2RYF7; -.
DR   PRIDE; E2RYF7; -.
DR   ProteomicsDB; 15280; -.
DR   GeneID; 285834; -.
DR   KEGG; hsa:285834; -.
DR   CTD; 285834; -.
DR   DisGeNET; 285834; -.
DR   GeneCards; HCG22; -.
DR   H-InvDB; HIX0165913; -.
DR   H-InvDB; HIX0166084; -.
DR   H-InvDB; HIX0166350; -.
DR   H-InvDB; HIX0166804; -.
DR   H-InvDB; HIX0167048; -.
DR   H-InvDB; HIX0167336; -.
DR   H-InvDB; HIX0207400; -.
DR   HGNC; HGNC:27780; HCG22.
DR   MIM; 613918; gene.
DR   neXtProt; NX_E2RYF7; -.
DR   InParanoid; E2RYF7; -.
DR   OrthoDB; 1369254at2759; -.
DR   GenomeRNAi; 285834; -.
DR   PRO; PR:E2RYF7; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032059; Mucin-like.
DR   InterPro; IPR037648; PBMUCL2.
DR   PANTHER; PTHR22467; PTHR22467; 2.
DR   Pfam; PF16058; Mucin-like; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    251       Protein PBMUCL2.
FT                                /FTId=PRO_0000410471.
FT   REGION      153    251       15 X 11 AA approximate repeats.
FT   COMPBIAS     89    248       Thr-rich.
FT   CARBOHYD    120    120       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   251 AA;  26282 MW;  CC3DEAC2A4617A1F CRC64;
     MPRYVPLLLL LLLLRCSERG GGVNFGEKDA KVPGTWRDGV RVPGEGASWD SDRASPERRY
     GIVGLSQSIS TKHPETSPKD SRIRENDVTA DGRTTEDHIT ADPGTTEDSV TADPGTTEDN
     VTVDPGTTEG SVTADPATTK DYVSADPGTT KDSVTADPGT TENFVTADPG TTKDSITADP
     RTTEDSVTAD PGTTKHSITV DPGTTEDSVT ADPGTTKHSI TADPGTTEDS VTADPGTTED
     ETTKHGDTHL L
//