ID   MUC22_HUMAN             Reviewed;        1773 AA.
AC   E2RYF6; H3BQR8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   16-JAN-2019, entry version 52.
DE   RecName: Full=Mucin-22;
DE   AltName: Full=Panbronchiolitis-related mucin-like protein 1;
DE   Flags: Precursor;
GN   Name=MUC22; Synonyms=G4, PBMUCL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, AND VARIANT
RP   ASP-1712.
RC   TISSUE=Lung;
RX   PubMed=20981447; DOI=10.1007/s00439-010-0906-4;
RA   Hijikata M., Matsushita I., Tanaka G., Tsuchiya T., Itoh H.,
RA   Tokunaga K., Ohashi J., Homma S., Kobashi Y., Taguchi Y., Azuma A.,
RA   Kudoh S., Keicho N.;
RT   "Molecular cloning of two novel mucin-like genes in the disease-
RT   susceptibility locus for diffuse panbronchiolitis.";
RL   Hum. Genet. 129:117-128(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in lung by serous cells of the
CC       submucosal gland (at protein level). Detected in the placenta,
CC       lung and testis. {ECO:0000269|PubMed:20981447}.
CC   -!- INDUCTION: Up-regulated by poly(I:C).
CC       {ECO:0000269|PubMed:20981447}.
CC   -!- WEB RESOURCE: Name=Mucin database;
CC       URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR   EMBL; AB560770; BAJ24154.1; -; mRNA.
DR   EMBL; AB600271; BAJ33462.1; -; mRNA.
DR   EMBL; AB600272; BAJ33463.1; -; mRNA.
DR   EMBL; AL669830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59003.1; -.
DR   RefSeq; NP_001185744.1; NM_001198815.1.
DR   RefSeq; NP_001305413.1; NM_001318484.1.
DR   UniGene; Hs.582967; -.
DR   ProteinModelPortal; E2RYF6; -.
DR   STRING; 9606.ENSP00000455906; -.
DR   iPTMnet; E2RYF6; -.
DR   PhosphoSitePlus; E2RYF6; -.
DR   BioMuta; MUC22; -.
DR   PaxDb; E2RYF6; -.
DR   PRIDE; E2RYF6; -.
DR   ProteomicsDB; 15279; -.
DR   Ensembl; ENST00000561890; ENSP00000455906; ENSG00000261272.
DR   GeneID; 100507679; -.
DR   KEGG; hsa:100507679; -.
DR   UCSC; uc063mxr.1; human.
DR   CTD; 100507679; -.
DR   DisGeNET; 100507679; -.
DR   EuPathDB; HostDB:ENSG00000261272.1; -.
DR   GeneCards; MUC22; -.
DR   H-InvDB; HIX0164915; -.
DR   H-InvDB; HIX0166030; -.
DR   H-InvDB; HIX0166233; -.
DR   H-InvDB; HIX0167061; -.
DR   H-InvDB; HIX0167293; -.
DR   H-InvDB; HIX0167600; -.
DR   HGNC; HGNC:39755; MUC22.
DR   MIM; 613917; gene.
DR   neXtProt; NX_E2RYF6; -.
DR   OpenTargets; ENSG00000261272; -.
DR   eggNOG; ENOG410KGW0; Eukaryota.
DR   eggNOG; ENOG4110RWV; LUCA.
DR   GeneTree; ENSGT00940000164570; -.
DR   InParanoid; E2RYF6; -.
DR   OMA; CTEETEN; -.
DR   OrthoDB; 1320016at2759; -.
DR   GenomeRNAi; 100507679; -.
DR   PRO; PR:E2RYF6; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000261272; Expressed in 10 organ(s), highest expression level in esophagus mucosa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028199; Mucin_dom.
DR   Pfam; PF14654; Epiglycanin_C; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Membrane; Polymorphism; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27   1773       Mucin-22.
FT                                /FTId=PRO_0000410470.
FT   TOPO_DOM     27   1660       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1661   1681       Helical. {ECO:0000255}.
FT   TOPO_DOM   1682   1773       Cytoplasmic. {ECO:0000255}.
FT   REGION      153   1514       124 X 10 AA approximate repeats.
FT   COMPBIAS     28   1649       Thr-rich.
FT   VARIANT    1712   1712       N -> D (in dbSNP:rs4248153).
FT                                {ECO:0000269|PubMed:20981447}.
FT                                /FTId=VAR_065357.
FT   CONFLICT     57     57       S -> T (in Ref. 1; BAJ24154/BAJ33462/
FT                                BAJ33463). {ECO:0000305}.
SQ   SEQUENCE   1773 AA;  173478 MW;  A25C9C6C4A5AC924 CRC64;
     MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA STMASTSALT
     TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD SGTTIASTRT FTTGSDTTTG
     STAGSETIVA STTVSGTTTT FTIASTTVPE TTMASSTTST AGSEKTMASS IISETTMAST
     TGSETATVST TGSETTTTST ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT
     STADSKVITA SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP
     SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS TAGSETTTVS
     ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS TVGSETTTAY TADSETTAAS
     TTGSEMTTVF TAGSETITPS TAGSETTTVS TAGSETTTVS TTGSETTTAS TAHSETTAAS
     TMGSETTKVS TAGSETTVST AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST
     TGSEPTMAST MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST
     TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST TGSETTTVSI
     TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST SDSETTTAST EGSETTTVTT
     AGSETKTAYT TGSETTTASN TGLETTTVFT IGSDTTTAST EGSETTAVSA TGSEMTTVST
     EGSENTTVST TGSETTTVST TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST
     AGSETTTVST ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST
     TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT GSETTKVSTT
     GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE GSETTSASTT GSETTTASTT
     SSETTMASIM GSETTMASTI GSETTKVSTA SSKMTTVFTE NSETTIASTT ASETTTVSTA
     GSETIPASTA GSETTTTTST EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST
     EGSETTTTST EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST
     TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI EGSETTTVSS
     TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT TGSETTTTST EGSETTTVST
     TGSETTTAST ADLETTTVST SGSGTTTAST AGSETTTVYI TGSKTTTAST EGSEATTVST
     TSSETTTAST TGSEMTTVFT TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST
     AGSETTTAST AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST
     ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI TNTPMSGTRT
     TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT STMGASSTTS AHGVRTTTGS
     TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN VIKPSGYLQP WAIILISLAA VVAAVGLSVG
     LSFCLRNLFF PLRYCGIYYP HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT
     HGFGYGVGHG LSHIHGDGYG VNHGGHYGHG GGH
//