ID   E0CX15_HUMAN            Unreviewed;       745 AA.
AC   E0CX15;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   05-DEC-2018, entry version 54.
DE   SubName: Full=Netrin receptor UNC5C {ECO:0000313|Ensembl:ENSP00000426924};
DE   Flags: Fragment;
GN   Name=UNC5C {ECO:0000313|Ensembl:ENSP00000426924};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426924, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426924, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426924}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC097656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E0CX15; -.
DR   PeptideAtlas; E0CX15; -.
DR   PRIDE; E0CX15; -.
DR   Ensembl; ENST00000513796; ENSP00000426924; ENSG00000182168.
DR   UCSC; uc062yhk.1; human.
DR   EuPathDB; HostDB:ENSG00000182168.14; -.
DR   HGNC; HGNC:12569; UNC5C.
DR   OpenTargets; ENSG00000182168; -.
DR   eggNOG; KOG1480; Eukaryota.
DR   eggNOG; ENOG410XRS6; LUCA.
DR   GeneTree; ENSGT00940000154692; -.
DR   ChiTaRS; UNC5C; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000182168; Expressed in 159 organ(s), highest expression level in lung.
DR   ExpressionAtlas; E0CX15; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; PTHR12582; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF82895; SSF82895; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E0CX15};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     39       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        40    745       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003133267.
FT   TRANSMEM    396    421       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      175    256       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      549    692       ZU5. {ECO:0000259|PROSITE:PS51145}.
FT   NON_TER     745    745       {ECO:0000313|Ensembl:ENSP00000426924}.
SQ   SEQUENCE   745 AA;  82326 MW;  304762B2EDD6073B CRC64;
     MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP
     LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR
     EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL
     EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV
     AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE
     GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK
     NCTDGLCMQS FIYPISTEQR TQNEYGFSSA PDSDDVALYV GIVIAVIVCL AISVVVALFV
     YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD
     KIPMTNSPIL DPLPNLKIKV YNTSGAVTPQ DDLSEFTSKL SPQMTQSLLE NEALSLKNQS
     LARQTDPSCT AFGSFNSLGG HLIVPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKETMRPPM
     DDSQTLLTPV VSCGPPGALL TRPVVLTMHH CADPNTEDWK ILLKNQAAQG QWEDVVVVGE
     ENFTTPCYIQ LDAEACHILT ENLSTYALVG HSTTKAAAKR LKLAIFGPLC CSSLEYSIRV
     YCLDDTQDAL KEILHLERQM GGQLL
//