ID   D9IPD9_HUMAN            Unreviewed;        89 AA.
AC   D9IPD9;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   05-DEC-2018, entry version 63.
DE   SubName: Full=Activin A receptor type II-like kinase 1 variant 3 {ECO:0000313|EMBL:ADJ79922.1};
DE   SubName: Full=Activin A receptor type II-like kinase 1 variant 4 {ECO:0000313|EMBL:ADJ79923.1};
DE   SubName: Full=Serine/threonine-protein kinase receptor R3 {ECO:0000313|Ensembl:ENSP00000455848};
DE   Flags: Fragment;
GN   Name=ACVRL1 {ECO:0000313|EMBL:ADJ79922.1,
GN   ECO:0000313|Ensembl:ENSP00000455848};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADJ79922.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455848, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|EMBL:ADJ79922.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20587022; DOI=10.1186/1471-2199-11-51;
RA   Garrido-Martin E.M., Blanco F.J., Fernandez-L A., Langa C., Vary C.P.,
RA   Lee U.E., Friedman S.L., Botella L.M., Bernabeu C.;
RT   "Characterization of the human Activin-A receptor type II-like kinase
RT   1 (ACVRL1) promoter and its regulation by Sp1.";
RL   BMC Mol. Biol. 11:51-51(2010).
RN   [3] {ECO:0000313|Ensembl:ENSP00000455848}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC025259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; HM161905; ADJ79922.1; -; mRNA.
DR   EMBL; HM161906; ADJ79923.1; -; mRNA.
DR   UniGene; Hs.591026; -.
DR   PeptideAtlas; D9IPD9; -.
DR   PRIDE; D9IPD9; -.
DR   Ensembl; ENST00000551576; ENSP00000455848; ENSG00000139567.
DR   UCSC; uc058oeo.1; human.
DR   EuPathDB; HostDB:ENSG00000139567.12; -.
DR   HGNC; HGNC:175; ACVRL1.
DR   OpenTargets; ENSG00000139567; -.
DR   eggNOG; KOG2052; Eukaryota.
DR   eggNOG; ENOG410XQT0; LUCA.
DR   GeneTree; ENSGT00940000161446; -.
DR   ChiTaRS; ACVRL1; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139567; Expressed in 181 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; D9IPD9; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Kinase {ECO:0000313|EMBL:ADJ79922.1};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D9IPD9};
KW   Receptor {ECO:0000313|EMBL:ADJ79922.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:ADJ79922.1}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22     89       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014088080.
FT   NON_TER      89     89       {ECO:0000313|EMBL:ADJ79922.1,
FT                                ECO:0000313|Ensembl:ENSP00000455848}.
SQ   SEQUENCE   89 AA;  9868 MW;  D80F3E39F8486638 CRC64;
     MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW CTVVLVREEG
     RHPQEHRGCG NLHRELCRGR PTEFVNHYC
//