ID   D9IDM5_HUMAN            Unreviewed;       651 AA.
AC   D9IDM5;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=LIR-1 {ECO:0000313|EMBL:ADJ55946.1};
DE   SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 1 {ECO:0000313|Ensembl:ENSP00000379623};
GN   Name=LILRB1 {ECO:0000313|EMBL:ADJ55946.1,
GN   ECO:0000313|Ensembl:ENSP00000379623};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADJ55946.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379623, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|EMBL:ADJ55946.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20600445; DOI=10.1016/j.humimm.2010.06.015;
RA   Davidson C.L., Li N.L., Burshtyn D.N.;
RT   "LILRB1 polymorphism and surface phenotypes of natural killer cells.";
RL   Hum. Immunol. 71:942-949(2010).
RN   [3] {ECO:0000313|Ensembl:ENSP00000379623}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC245036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; HM135396; ADJ55946.1; -; Genomic_DNA.
DR   RefSeq; NP_001075108.2; NM_001081639.3.
DR   UniGene; Hs.667388; -.
DR   jPOST; D9IDM5; -.
DR   PeptideAtlas; D9IDM5; -.
DR   PRIDE; D9IDM5; -.
DR   Ensembl; ENST00000396332; ENSP00000379623; ENSG00000104972.
DR   GeneID; 10859; -.
DR   UCSC; uc032ief.2; human.
DR   CTD; 10859; -.
DR   EuPathDB; HostDB:ENSG00000104972.15; -.
DR   HGNC; HGNC:6605; LILRB1.
DR   OpenTargets; ENSG00000104972; -.
DR   eggNOG; ENOG410IKJD; Eukaryota.
DR   eggNOG; ENOG41116BR; LUCA.
DR   GeneTree; ENSGT00940000153160; -.
DR   OrthoDB; 1000446at2759; -.
DR   ChiTaRS; LILRB1; human.
DR   GenomeRNAi; 10859; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104972; Expressed in 179 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; D9IDM5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:D9IDM5,
KW   ECO:0000213|PeptideAtlas:D9IDM5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    651       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014088082.
FT   TRANSMEM    459    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    115       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      313    409       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   651 AA;  70976 MW;  82F752D3CE2DA351 CRC64;
     MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL
     YREKKTAPWI TRIPQELVKK GQFPIPSITW EHTGRYRCYY GSDTAGRSES SDPLELVVTG
     AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA
     IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE
     TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA
     HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE
     GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS
     GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF
     LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ
     PEDGVEMDTR QSPHDEDPQA VTYAEVKHSR PRREMASPPS PLSGEFLDTK DRQAEEDRQM
     DTEAAASEAP QDVTYAQLHS LTLRREATEP PPSQEGPSPA VPSIYATLAI H
//