ID   D8MIV0_HUMAN            Unreviewed;       162 AA.
AC   D8MIV0;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   05-DEC-2018, entry version 54.
DE   SubName: Full=Calcitonin receptor {ECO:0000313|EMBL:CBN80565.1, ECO:0000313|Ensembl:ENSP00000353385};
GN   Name=CALCR {ECO:0000313|EMBL:CBN80565.1,
GN   ECO:0000313|Ensembl:ENSP00000353385};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CBN80565.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000353385, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|EMBL:CBN80565.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1 {ECO:0000313|EMBL:CBN80565.1};
RC   TISSUE=Cartilage {ECO:0000313|EMBL:CBN80565.1};
RA   Bonnefond C.;
RT   "Identification of the human calcitonin receptor expressed in
RT   osteoarthritis chondrocytes.";
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CBN80565.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1 {ECO:0000313|EMBL:CBN80565.1};
RC   TISSUE=Cartilage {ECO:0000313|EMBL:CBN80565.1};
RA   Segovia-Silvestre T.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000353385}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC003078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FN994993; CBN80565.1; -; mRNA.
DR   UniGene; Hs.489127; -.
DR   Ensembl; ENST00000360249; ENSP00000353385; ENSG00000004948.
DR   UCSC; uc064fka.1; human.
DR   EuPathDB; HostDB:ENSG00000004948.13; -.
DR   HGNC; HGNC:1440; CALCR.
DR   OpenTargets; ENSG00000004948; -.
DR   eggNOG; KOG4564; Eukaryota.
DR   eggNOG; ENOG410XRS2; LUCA.
DR   GeneTree; ENSGT00940000155380; -.
DR   ChiTaRS; CALCR; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000004948; Expressed in 52 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; D8MIV0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
DR   InterPro; IPR001688; GPCR_2_calcitonin_rcpt.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   PANTHER; PTHR12011:SF84; PTHR12011:SF84; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR00361; CALCITONINR.
DR   PRINTS; PR01350; CTRFAMILY.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Receptor {ECO:0000313|EMBL:CBN80565.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    162       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014569988.
FT   DOMAIN       54    138       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
SQ   SEQUENCE   162 AA;  19072 MW;  5CB09E98ED61A163 CRC64;
     MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ
     QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK
     HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSCQF SP
//