ID   D6W5L6_HUMAN            Unreviewed;       393 AA.
AC   D6W5L6;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=Pulmonary surfactant-associated protein B {ECO:0000313|Ensembl:ENSP00000386346};
DE   SubName: Full=Surfactant, pulmonary-associated protein B, isoform CRA_a {ECO:0000313|EMBL:EAW99488.1};
GN   Name=SFTPB {ECO:0000313|EMBL:EAW99488.1,
GN   ECO:0000313|Ensembl:ENSP00000386346};
GN   ORFNames=hCG_34600 {ECO:0000313|EMBL:EAW99488.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:EAW99488.1};
RN   [1] {ECO:0000313|EMBL:EAW99488.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386346, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3] {ECO:0000313|EMBL:EAW99488.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000386346}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC012454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAW99487.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAW99488.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAW99489.1; -; Genomic_DNA.
DR   RefSeq; NP_000533.3; NM_000542.3.
DR   RefSeq; NP_942140.2; NM_198843.2.
DR   RefSeq; XP_005264544.1; XM_005264487.2.
DR   RefSeq; XP_016860191.1; XM_017004702.1.
DR   UniGene; Hs.512690; -.
DR   SMR; D6W5L6; -.
DR   PeptideAtlas; D6W5L6; -.
DR   PRIDE; D6W5L6; -.
DR   DNASU; 6439; -.
DR   Ensembl; ENST00000409383; ENSP00000386346; ENSG00000168878.
DR   GeneID; 6439; -.
DR   KEGG; hsa:6439; -.
DR   UCSC; uc002sqh.4; human.
DR   CTD; 6439; -.
DR   EuPathDB; HostDB:ENSG00000168878.16; -.
DR   HGNC; HGNC:10801; SFTPB.
DR   OpenTargets; ENSG00000168878; -.
DR   eggNOG; KOG1340; Eukaryota.
DR   eggNOG; ENOG410XSI5; LUCA.
DR   GeneTree; ENSGT00940000161711; -.
DR   HOGENOM; HOG000115745; -.
DR   OMA; AQGPEFW; -.
DR   OrthoDB; 865505at2759; -.
DR   TreeFam; TF316942; -.
DR   ChiTaRS; SFTPB; human.
DR   GenomeRNAi; 6439; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000168878; Expressed in 211 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; D6W5L6; baseline and differential.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR003119; SAP_A.
DR   InterPro; IPR007856; SapB_1.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR008373; Saposin.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   Pfam; PF02199; SapA; 1.
DR   Pfam; PF05184; SapB_1; 1.
DR   Pfam; PF03489; SapB_2; 2.
DR   PRINTS; PR01797; SAPOSIN.
DR   SMART; SM00162; SAPA; 1.
DR   SMART; SM00741; SapB; 3.
DR   SUPFAM; SSF47862; SSF47862; 3.
DR   PROSITE; PS51110; SAP_A; 1.
DR   PROSITE; PS50015; SAP_B; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D6W5L6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36    393       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014088025.
FT   DOMAIN       37     77       Saposin A-type.
FT                                {ECO:0000259|PROSITE:PS51110}.
FT   DOMAIN       77    159       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
FT   DOMAIN      216    293       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
FT   DOMAIN      307    382       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
SQ   SEQUENCE   393 AA;  43347 MW;  AF32E2C83D8F3E7B CRC64;
     MHQAGYPGCR GAMAESHLLQ WLLLLLPTLC GPGTAAWTTS SLACAQGPEF WCQSLEQALQ
     CRALGHCLQE VWGHVGADDL CQECEDIVHI LNKMAKEAIF QDTMRKFLEQ ECNVLPLKLL
     MPQCNQVLDD YFPLVIDYFQ NQTDSNGICM HLGLCKSRQP EPEQEPGMSD PLPKPLRDPL
     PDPLLDKLVL PVLPGALQAR PGPHTQDLSE QQFPIPLPYC WLCRALIKRI QAMIPKGALA
     VAVAQVCRVV PLVAGGICQC LAERYSVILL DTLLGRMLPQ LVCRLVLRCS MDDSAGPRSP
     TGEWLPRDSE CHLCMSVTTQ AGNSSEQAIP QAMLQACVGS WLDREKCKQF VEQHTPQLLT
     LVPRGWDAHT TCQALGVCGT MSSPLQCIHS PDL
//