ID D6RJI3_HUMAN Unreviewed; 1473 AA. AC D6RJI3; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 13-FEB-2019, entry version 79. DE SubName: Full=Fibrillin-2 {ECO:0000313|Ensembl:ENSP00000425596}; GN Name=FBN2 {ECO:0000313|Ensembl:ENSP00000425596}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425596, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000425596, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000425596} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC025169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC034235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC114276; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510259; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RJI3; -. DR jPOST; D6RJI3; -. DR MaxQB; D6RJI3; -. DR PRIDE; D6RJI3; -. DR Ensembl; ENST00000508989; ENSP00000425596; ENSG00000138829. DR UCSC; uc003kuv.3; human. DR EuPathDB; HostDB:ENSG00000138829.10; -. DR HGNC; HGNC:3604; FBN2. DR OpenTargets; ENSG00000138829; -. DR eggNOG; ENOG410IR7H; Eukaryota. DR eggNOG; ENOG410XSTY; LUCA. DR GeneTree; ENSGT00940000153951; -. DR HOGENOM; HOG000186345; -. DR ChiTaRS; FBN2; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000138829; Expressed in 146 organ(s), highest expression level in placenta. DR ExpressionAtlas; D6RJI3; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro. DR Gene3D; 3.90.290.10; -; 5. DR InterPro; IPR026823; cEGF. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR011398; FBN. DR InterPro; IPR040872; Fibrillin_U_N. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR017878; TB_dom. DR InterPro; IPR036773; TB_dom_sf. DR PANTHER; PTHR24039; PTHR24039; 2. DR Pfam; PF12662; cEGF; 2. DR Pfam; PF07645; EGF_CA; 16. DR Pfam; PF18193; Fibrillin_U_N; 1. DR Pfam; PF12661; hEGF; 2. DR Pfam; PF00683; TB; 5. DR SMART; SM00181; EGF; 23. DR SMART; SM00179; EGF_CA; 21. DR SUPFAM; SSF57184; SSF57184; 7. DR SUPFAM; SSF57581; SSF57581; 5. DR PROSITE; PS00010; ASX_HYDROXYL; 20. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 15. DR PROSITE; PS50026; EGF_3; 22. DR PROSITE; PS01187; EGF_CA; 9. DR PROSITE; PS51364; TB; 5. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|EPD:D6RJI3, KW ECO:0000213|MaxQB:D6RJI3, ECO:0000213|PeptideAtlas:D6RJI3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 1473 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087421. FT DOMAIN 143 175 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 181 224 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 243 284 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 285 326 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 331 384 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 461 501 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 502 541 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 542 583 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 584 624 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 625 665 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 671 723 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 735 776 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 777 818 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 819 858 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 863 902 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 922 963 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 968 1019 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1040 1081 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1082 1124 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1125 1166 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1167 1208 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1209 1249 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1250 1291 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1292 1329 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1334 1374 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1375 1415 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1416 1457 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 147 157 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 165 174 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 506 516 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 823 833 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1473 AA; 157690 MW; A8E242BE9930E02A CRC64; MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVLQQCSVRC MNGGTCADDH CQCQKGYIGT YCGQPVCENG CQNGGRCIGP NRCACVYGFT GPQCERDYRT GPCFTQVNNQ MCQGQLTGIV CTKTLCCATI GRAWGHPCEM CPAQPQPCRR GFIPNIRTGA CQDVDECQAI PGICQGGNCI NTVGSFECRC PAGHKQSETT QKCEDIDECS IIPGICETGE CSNTVGSYFC VCPRGYVTST DGSRCIDQRT GMCFSGLVNG RCAQELPGRM TKMQCCCEPG RCWGIGTIPE ACPVRGSEEY RRLCMDGLPM GGIPGSAGSR PGGTGGNGFA PSGNGNGYGP GGTGFIPIPG GNGFSPGVGG AGVGAGGQGP IITGLTILNQ TIDICKHHAN LCLNGRCIPT VSSYRCECNM GYKQDANGDC IDVDECTSNP CTNGDCVNTP GSYYCKCHAG FQRTPTKQAC IDIDECIQNG VLCKNGRCVN TDGSFQCICN AGFELTTDGK NCVDHDECTT TNMCLNGMCI NEDGSFKCIC KPGFVLAPNG RYCTDVDECQ TPGICMNGHC INSEGSFRCD CPPGLAVGMD GRVCVDTHMR STCYGGIKKG VCVRPFPGAV TKSECCCANP DYGFGEPCQP CPAKNSAEFH GLCSSGVGIT VDGRDINECA LDPDICANGI CENLRGSYRC NCNSGYEPDA SGRNCIDIDE CLVNRLLCDN GLCRNTPGSY SCTCPPGYVF RTETETCEDI NECESNPCVN GACRNNLGSF NCECSPGSKL SSTGLICIDS LKGTCWLNIQ DSRCEVNING ATLKSECCAT LGAAWGSPCE RCELDTACPR GLARIKGVTC EDVNECEVFP GVCPNGRCVN SKGSFHCECP EGLTLDGTGR VCLDIRMEQC YLKWDEDECI HPVPGKFRMD ACCCAVGAAW GTECEECPKP GTKEYETLCP RGAGFANRGD VLTGRPFYKD INECKAFPGM CTYGKCRNTI GSFKCRCNSG FALDMEERNC TDIDECRISP DLCGSGICVN TPGSFECECF EGYESGFMMM KNCMDIDECE RNPLLCRGGT CVNTEGSFQC DCPLGHELSP SREDCVDINE CSLSDNLCRN GKCVNMIGTY QCSCNPGYQA TPDRQGCTDI DECMIMNGGC DTQCTNSEGS YECSCSEGYA LMPDGRSCAD IDECENNPDI CDGGQCTNIP GEYRCLCYDG FMASMDMKTC IDVNECDLNS NICMFGECEN TKGSFICHCQ LGYSVKKGTT GCTDVDECEI GAHNCDMHAS CLNIPGSFKC SCREGWIGNG IKCIDLDECS NGTHQCSINA QCVNTPGSYR CACSEGFTGD GFTCSDVDEC AENINLCENG QCLNVPGAYR CECEMGFTPA SDSRSCQGGS PGFQLIFKLD QPQ //