ID   D6RJG9_HUMAN            Unreviewed;       833 AA.
AC   D6RJG9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Sorting nexin-14 {ECO:0000313|Ensembl:ENSP00000425630};
DE   Flags: Fragment;
GN   Name=SNX14 {ECO:0000313|Ensembl:ENSP00000425630};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425630, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425630, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425630}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AL136082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL589666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RJG9; -.
DR   IntAct; D6RJG9; 1.
DR   jPOST; D6RJG9; -.
DR   MaxQB; D6RJG9; -.
DR   PeptideAtlas; D6RJG9; -.
DR   PRIDE; D6RJG9; -.
DR   Ensembl; ENST00000515216; ENSP00000425630; ENSG00000135317.
DR   UCSC; uc063pwx.1; human.
DR   EuPathDB; HostDB:ENSG00000135317.12; -.
DR   HGNC; HGNC:14977; SNX14.
DR   OpenTargets; ENSG00000135317; -.
DR   eggNOG; ENOG410IMHX; Eukaryota.
DR   eggNOG; ENOG410XS0F; LUCA.
DR   GeneTree; ENSGT00940000153427; -.
DR   HOGENOM; HOG000043107; -.
DR   ChiTaRS; SNX14; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000135317; Expressed in 195 organ(s), highest expression level in intestine.
DR   ExpressionAtlas; D6RJG9; baseline and differential.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; Phox.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RJG9,
KW   ECO:0000213|MaxQB:D6RJG9, ECO:0000213|PeptideAtlas:D6RJG9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    833       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087693.
FT   DOMAIN       57    231       PXA. {ECO:0000259|PROSITE:PS51207}.
FT   DOMAIN      263    395       RGS. {ECO:0000259|PROSITE:PS50132}.
FT   DOMAIN      488    608       PX. {ECO:0000259|PROSITE:PS50195}.
FT   NON_TER     833    833       {ECO:0000313|Ensembl:ENSP00000425630}.
SQ   SEQUENCE   833 AA;  97126 MW;  122841E46739338F CRC64;
     MKMKTFVIIH FHLIQLGLQE LFPQGHSCAV CGKVKCKRHR PSLLLENYQP WLDLKISSKV
     DASLSEVLEL VLENFVYPWY RDVTDDESFV DELRITLRFF ASVLIRRIHK VDIPSIITKK
     LLKAAMKHIE VIVKARQKVK NTEFLQQAAL EEYGPELHVA LRSRRDELHY LRKLTELLFP
     YILPPKATDC RSLTLLIREI LSGSVFLPSL DFLADPDTVN HLLIIFIDDS PPEKATEPAS
     PLVPFLQKFA EPRNKKPSVL KLELKQIREQ QDLLFRFMNF LKQEGAVHVL QFCLTVEEFN
     DRILRPELSN DEMLSLHEEL QKIYKTYCLD ESIDKIRFDP FIVEEIQRIA EGPYIDVVKL
     QTMRCLFEAY EHVLSLLENV FTPMFCHSDE YFRQLLRGAE SPTRNSKLNR NTQKRGESFG
     ISRIGSKIKG VFKSTTMEGA MLPNYGVAEG EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL
     AAWKISIPYV DFFEDPSSER KEKKERIPVF CIDVERNDRR AVGHEPEHWS VYRRYLEFYV
     LESKLTEFHG AFPDAQLPSK RIIGPKNYEF LKSKREEFQE YLQKLLQHPE LSNSQLLADF
     LSPNGGETQF LDKILPDVNL GKIIKSVPGK LMKEKGQHLE PFIMNFINSC ESPKPKPSRP
     ELTILSPTSE NNKKLFNDLF KNNANRAENT ERKQNQNYFM EVMTVEGVYD YLMYVGRVVF
     QVPDWLHHLL MGTRILFKNT LEMYTDYYLQ CKLEQLFQEH RLVSLITLLR DAIFCENTEP
     RSLQDKQKGA KQTFEEMMNY IPDLLVKCIG EETKYESIRL LFDGLQQPVL NKQ
//