ID   D6RJG0_HUMAN            Unreviewed;       436 AA.
AC   D6RJG0;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   05-DEC-2018, entry version 56.
DE   SubName: Full=Cadherin-10 {ECO:0000313|Ensembl:ENSP00000425653};
GN   Name=CDH10 {ECO:0000313|Ensembl:ENSP00000425653};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425653, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425653, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425653}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS01075634}.
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DR   EMBL; AC010387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RJG0; -.
DR   SMR; D6RJG0; -.
DR   MaxQB; D6RJG0; -.
DR   PeptideAtlas; D6RJG0; -.
DR   PRIDE; D6RJG0; -.
DR   Ensembl; ENST00000510477; ENSP00000425653; ENSG00000040731.
DR   UCSC; uc063cph.1; human.
DR   EuPathDB; HostDB:ENSG00000040731.10; -.
DR   HGNC; HGNC:1749; CDH10.
DR   OpenTargets; ENSG00000040731; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000154187; -.
DR   HOGENOM; HOG000231252; -.
DR   ChiTaRS; CDH10; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000040731; Expressed in 119 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; D6RJG0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; PTHR24027; 1.
DR   Pfam; PF00028; Cadherin; 3.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 3.
DR   SUPFAM; SSF49313; SSF49313; 4.
DR   PROSITE; PS00232; CADHERIN_1; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS01075623};
KW   Cell membrane {ECO:0000256|SAAS:SAAS01075618};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAAS:SAAS01075618};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01075609};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RJG0,
KW   ECO:0000213|PeptideAtlas:D6RJG0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    436       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087655.
FT   DOMAIN       77    158       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      182    267       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      291    383       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   436 AA;  49317 MW;  E63B39725EDCD2D6 CRC64;
     MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ
     FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE
     EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV
     QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK
     DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK
     NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY
     YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRQ
     SQRDNTRGCF CENFGC
//