ID   D6RJA3_HUMAN            Unreviewed;       157 AA.
AC   D6RJA3;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Neuroendocrine convertase 1 {ECO:0000313|Ensembl:ENSP00000427294};
DE   Flags: Fragment;
GN   Name=PCSK1 {ECO:0000313|Ensembl:ENSP00000427294};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427294, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427294, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427294}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RJA3; -.
DR   jPOST; D6RJA3; -.
DR   PeptideAtlas; D6RJA3; -.
DR   PRIDE; D6RJA3; -.
DR   Ensembl; ENST00000509190; ENSP00000427294; ENSG00000175426.
DR   UCSC; uc063foh.1; human.
DR   EuPathDB; HostDB:ENSG00000175426.10; -.
DR   HGNC; HGNC:8743; PCSK1.
DR   OpenTargets; ENSG00000175426; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00940000157385; -.
DR   ChiTaRS; PCSK1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000175426; Expressed in 131 organ(s), highest expression level in type B pancreatic cell.
DR   ExpressionAtlas; D6RJA3; baseline and differential.
DR   Gene3D; 3.30.70.850; -; 1.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   Pfam; PF16470; S8_pro-domain; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D6RJA3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    157       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413430.
FT   DOMAIN       34    110       S8_pro-domain.
FT                                {ECO:0000259|Pfam:PF16470}.
FT   NON_TER     157    157       {ECO:0000313|Ensembl:ENSP00000427294}.
SQ   SEQUENCE   157 AA;  18273 MW;  603A776D44B241F4 CRC64;
     MERRAWSLQC TAFVLFCAWC ALNSAKAKRQ FVNEWAAEIP GGPEAASAIA EELGYDLLGQ
     IGSLENHYLF KHKNHPRRSR RSAFHITKRL SDDDRVIWAE QQYEKERSKR SALRDSALNL
     FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP VWQKGIT
//