ID   D6RIY7_HUMAN            Unreviewed;       314 AA.
AC   D6RIY7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Tumor suppressor candidate 3 {ECO:0000313|Ensembl:ENSP00000425777};
GN   Name=TUSC3 {ECO:0000313|Ensembl:ENSP00000425777};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425777, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425777, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425777}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RIY7; -.
DR   jPOST; D6RIY7; -.
DR   MaxQB; D6RIY7; -.
DR   PeptideAtlas; D6RIY7; -.
DR   PRIDE; D6RIY7; -.
DR   Ensembl; ENST00000506802; ENSP00000425777; ENSG00000104723.
DR   UCSC; uc064klj.1; human.
DR   EuPathDB; HostDB:ENSG00000104723.20; -.
DR   HGNC; HGNC:30242; TUSC3.
DR   OpenTargets; ENSG00000104723; -.
DR   eggNOG; KOG2603; Eukaryota.
DR   eggNOG; ENOG410XR1F; LUCA.
DR   GeneTree; ENSGT00390000012030; -.
DR   HOGENOM; HOG000231301; -.
DR   ChiTaRS; TUSC3; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104723; Expressed in 211 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; D6RIY7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12692; PTHR12692; 1.
DR   Pfam; PF04756; OST3_OST6; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:D6RIY7,
KW   ECO:0000213|MaxQB:D6RIY7, ECO:0000213|PeptideAtlas:D6RIY7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     41       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        42    314       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087415.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    302       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   314 AA;  35736 MW;  E4E246F14B001792 CRC64;
     MGARGAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA EKVEQLMEWS
     SRRSIFRMNG DKFRKFIKAP PRNYSMIVMF TALQPQRQCS VCRQANEEYQ ILANSWRYSS
     AFCNKLFFSM VDYDEGTDVF QQLNMNSAPT FMHFPPKGRP KRADTFDLQR IGFAAEQLAK
     WIADRTDVHI RVFRPPNYSG TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF
     AMTSGQMWNH IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLNAA ITMGMVLLNE
     AATSKGDVGK RRTF
//