ID   D6RIU5_HUMAN            Unreviewed;        65 AA.
AC   D6RIU5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Serine protease inhibitor Kazal-type 1 {ECO:0000313|Ensembl:ENSP00000427376};
GN   Name=SPINK1 {ECO:0000313|Ensembl:ENSP00000427376};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427376, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427376, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427376}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC011352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RIU5; -.
DR   jPOST; D6RIU5; -.
DR   PeptideAtlas; D6RIU5; -.
DR   PRIDE; D6RIU5; -.
DR   Ensembl; ENST00000510027; ENSP00000427376; ENSG00000164266.
DR   UCSC; uc063ikg.1; human.
DR   EuPathDB; HostDB:ENSG00000164266.10; -.
DR   HGNC; HGNC:11244; SPINK1.
DR   OpenTargets; ENSG00000164266; -.
DR   eggNOG; KOG3649; Eukaryota.
DR   eggNOG; ENOG410YC3T; LUCA.
DR   GeneTree; ENSGT00530000064228; -.
DR   HOGENOM; HOG000090244; -.
DR   ChiTaRS; SPINK1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164266; Expressed in 129 organ(s), highest expression level in islet of Langerhans.
DR   ExpressionAtlas; D6RIU5; baseline and differential.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001239; Prot_inh_Kazal-m.
DR   Pfam; PF00050; Kazal_1; 1.
DR   PRINTS; PR00290; KAZALINHBTR.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RIU5,
KW   ECO:0000213|PeptideAtlas:D6RIU5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24     65       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087685.
FT   DOMAIN       26     65       Kazal-like.
FT                                {ECO:0000259|PROSITE:PS51465}.
SQ   SEQUENCE   65 AA;  6966 MW;  569ADA65A55A63B6 CRC64;
     MKVTGIFLLS ALALLSLSGN TGADSLGREA KCYNELNGCT KIYDPVCGTD GNTYPNECVL
     CFENR
//