ID D6RIH8_HUMAN Unreviewed; 590 AA. AC D6RIH8; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 61. DE SubName: Full=Cadherin-18 {ECO:0000313|Ensembl:ENSP00000425854}; GN Name=CDH18 {ECO:0000313|Ensembl:ENSP00000425854}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425854, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000425854, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000425854} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01075634}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC025173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC093221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC118463; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF454884; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457863; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RIH8; -. DR jPOST; D6RIH8; -. DR PeptideAtlas; D6RIH8; -. DR PRIDE; D6RIH8; -. DR Ensembl; ENST00000511273; ENSP00000425854; ENSG00000145526. DR UCSC; uc063coe.1; human. DR EuPathDB; HostDB:ENSG00000145526.11; -. DR HGNC; HGNC:1757; CDH18. DR OpenTargets; ENSG00000145526; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000157512; -. DR HOGENOM; HOG000231252; -. DR ChiTaRS; CDH18; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000145526; Expressed in 102 organ(s), highest expression level in middle temporal gyrus. DR ExpressionAtlas; D6RIH8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR InterPro; IPR039808; Cadherin. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR PANTHER; PTHR24027; PTHR24027; 1. DR Pfam; PF00028; Cadherin; 4. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 4. DR SUPFAM; SSF49313; SSF49313; 5. DR PROSITE; PS00232; CADHERIN_1; 2. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Cell adhesion {ECO:0000256|SAAS:SAAS01075623}; KW Cell membrane {ECO:0000256|SAAS:SAAS01075618}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAAS:SAAS01075618, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|SAAS:SAAS01075609}; KW Proteomics identification {ECO:0000213|PeptideAtlas:D6RIH8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 590 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087404. FT TRANSMEM 547 570 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 76 157 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 181 266 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 290 382 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 405 486 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 590 AA; 65942 MW; D5244DDDFAFFD5DC CRC64; MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK DNEGEHIYTY LFIYVVSALT LYVIGFILIY TQTSCKSAFK VSLMLLCYDL //