ID   D6RI10_HUMAN            Unreviewed;       134 AA.
AC   D6RI10;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   07-NOV-2018, entry version 55.
DE   SubName: Full=Serine protease inhibitor Kazal-type 2 {ECO:0000313|Ensembl:ENSP00000425961};
GN   Name=SPINK2 {ECO:0000313|Ensembl:ENSP00000425961};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425961, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425961, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425961}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC022483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001258647.1; NM_001271718.1.
DR   UniGene; Hs.98243; -.
DR   ProteinModelPortal; D6RI10; -.
DR   MEROPS; I01.012; -.
DR   PeptideAtlas; D6RI10; -.
DR   PRIDE; D6RI10; -.
DR   Ensembl; ENST00000506738; ENSP00000425961; ENSG00000128040.
DR   GeneID; 6691; -.
DR   UCSC; uc031sel.2; human.
DR   CTD; 6691; -.
DR   EuPathDB; HostDB:ENSG00000128040.10; -.
DR   HGNC; HGNC:11245; SPINK2.
DR   OpenTargets; ENSG00000128040; -.
DR   GeneTree; ENSGT00530000064285; -.
DR   HOGENOM; HOG000090244; -.
DR   OMA; IREGGHN; -.
DR   PhylomeDB; D6RI10; -.
DR   GenomeRNAi; 6691; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000128040; Expressed in 109 organ(s), highest expression level in corpus epididymis.
DR   ExpressionAtlas; D6RI10; baseline and differential.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RI10,
KW   ECO:0000213|PeptideAtlas:D6RI10};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    134       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087455.
FT   DOMAIN       80    134       Kazal-like.
FT                                {ECO:0000259|PROSITE:PS51465}.
SQ   SEQUENCE   134 AA;  13891 MW;  095E186BCFC16428 CRC64;
     MALSVLRLAL LLLAVTFAGS ARSGPGERGP PEKSGFGSQT GGGPCPAPGG LGDGTRAPVT
     GGSPEDLPAS LIPQFGLFSK YRTPNCSQYR LPGCPRHFNP VCGSDMSTYA NECTLCMKIR
     EGGHNIKIIR NGPC
//