ID   D6RHH7_HUMAN            Unreviewed;       238 AA.
AC   D6RHH7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   12-SEP-2018, entry version 53.
DE   SubName: Full=Corticotropin-releasing factor-binding protein {ECO:0000313|Ensembl:ENSP00000426097};
GN   Name=CRHBP {ECO:0000313|Ensembl:ENSP00000426097};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426097, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426097, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426097}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC027342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RHH7; -.
DR   SMR; D6RHH7; -.
DR   PeptideAtlas; D6RHH7; -.
DR   PRIDE; D6RHH7; -.
DR   Ensembl; ENST00000506501; ENSP00000426097; ENSG00000145708.
DR   UCSC; uc010izx.4; human.
DR   EuPathDB; HostDB:ENSG00000145708.10; -.
DR   HGNC; HGNC:2356; CRHBP.
DR   OpenTargets; ENSG00000145708; -.
DR   eggNOG; ENOG410II3D; Eukaryota.
DR   eggNOG; ENOG4111JUQ; LUCA.
DR   GeneTree; ENSGT00390000001362; -.
DR   HOGENOM; HOG000004819; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145708; Expressed in 126 organ(s), highest expression level in metanephric glomerulus.
DR   ExpressionAtlas; D6RHH7; baseline and differential.
DR   GO; GO:0051424; F:corticotropin-releasing hormone binding; IEA:InterPro.
DR   InterPro; IPR008435; CRF-bd.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10278; PTHR10278; 1.
DR   Pfam; PF05428; CRF-BP; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D6RHH7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    238       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087608.
SQ   SEQUENCE   238 AA;  27082 MW;  4CFC8A9615B79A73 CRC64;
     MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC
     LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG
     EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL
     FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KVSCLLVS
//