ID   D6RHG4_HUMAN            Unreviewed;       226 AA.
AC   D6RHG4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Heparanase {ECO:0000313|Ensembl:ENSP00000426139};
GN   Name=HPSE {ECO:0000313|Ensembl:ENSP00000426139};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426139, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426139, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426139}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC114781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RHG4; -.
DR   jPOST; D6RHG4; -.
DR   MaxQB; D6RHG4; -.
DR   PeptideAtlas; D6RHG4; -.
DR   PRIDE; D6RHG4; -.
DR   Ensembl; ENST00000507150; ENSP00000426139; ENSG00000173083.
DR   UCSC; uc062xvt.1; human.
DR   EuPathDB; HostDB:ENSG00000173083.14; -.
DR   HGNC; HGNC:5164; HPSE.
DR   OpenTargets; ENSG00000173083; -.
DR   eggNOG; ENOG410IHNV; Eukaryota.
DR   eggNOG; ENOG410YDJW; LUCA.
DR   GeneTree; ENSGT00390000004874; -.
DR   ChiTaRS; HPSE; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000173083; Expressed in 131 organ(s), highest expression level in blood.
DR   ExpressionAtlas; D6RHG4; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:InterPro.
DR   InterPro; IPR005199; Glyco_hydro_79.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR14363; PTHR14363; 1.
DR   Pfam; PF03662; Glyco_hydro_79n; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RHG4,
KW   ECO:0000213|MaxQB:D6RHG4, ECO:0000213|PeptideAtlas:D6RHG4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36    226       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087449.
SQ   SEQUENCE   226 AA;  25443 MW;  6C15774AD8F1872F CRC64;
     MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
     IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
     QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
     GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNAS
//