ID D6RH31_HUMAN Unreviewed; 609 AA. AC D6RH31; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 70. DE SubName: Full=Nephronectin {ECO:0000313|Ensembl:ENSP00000426146}; DE Flags: Fragment; GN Name=NPNT {ECO:0000313|Ensembl:ENSP00000426146}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426146, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000426146, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000426146} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC109361; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RH31; -. DR STRING; 9606.ENSP00000389252; -. DR jPOST; D6RH31; -. DR PaxDb; D6RH31; -. DR PeptideAtlas; D6RH31; -. DR PRIDE; D6RH31; -. DR Ensembl; ENST00000503451; ENSP00000426146; ENSG00000168743. DR UCSC; uc062yue.1; human. DR EuPathDB; HostDB:ENSG00000168743.12; -. DR HGNC; HGNC:27405; NPNT. DR OpenTargets; ENSG00000168743; -. DR eggNOG; ENOG410IR6Z; Eukaryota. DR eggNOG; ENOG411039V; LUCA. DR GeneTree; ENSGT00930000150973; -. DR HOGENOM; HOG000059638; -. DR OMA; GGHSNWI; -. DR PhylomeDB; D6RH31; -. DR ChiTaRS; NPNT; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000168743; Expressed in 183 organ(s), highest expression level in thyroid gland. DR ExpressionAtlas; D6RH31; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd06263; MAM; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR000998; MAM_dom. DR Pfam; PF07645; EGF_CA; 3. DR Pfam; PF00629; MAM; 1. DR SMART; SM00181; EGF; 5. DR SMART; SM00179; EGF_CA; 3. DR SMART; SM00137; MAM; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 3. DR PROSITE; PS50026; EGF_3; 4. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS50060; MAM_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00602928}; KW Proteomics identification {ECO:0000213|MaxQB:D6RH31, KW ECO:0000213|PeptideAtlas:D6RH31}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 609 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087444. FT DOMAIN 73 104 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 136 175 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 216 260 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 261 301 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 467 609 MAM. {ECO:0000259|PROSITE:PS50060}. FT DISULFID 94 103 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT NON_TER 609 609 {ECO:0000313|Ensembl:ENSP00000426146}. SQ SEQUENCE 609 AA; 66916 MW; 0E54C2FDA351B1A7 CRC64; MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPFY VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG KTCNQDEHIP APLDQGSEQP LFQPLDHQAT SLPSRDLNEC GLKPRPCKHR CMNTYGSYKC YCLNGYMLMP DGSCSSALTC SMANCQYGCD VVKGQIRCQC PSPGLQLAPD GRTCVDVDEC ATGRASCPRF RQCVNTFGSY ICKCHKGFDL MYIGGKYQCH DIDECSLGQY QCSSFARCYN IRGSYKCKCK EGYQGDGLTC VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP PIITNRPTSK PTTRPTPKPT PIPTPPPPPP LPTELRTPLP PTTPERPTTG LTTIAPAAST PPGGITVDNR VQTDPQKPRG DVFIPRQPSN DLFEIFEIER GVSADDEAKD DPGVLVHSCN FDHGLCGWIR EKDNDLHWEP IRDPAGGQYL TVSAAKAPGG KAARLVLPLG RLMHSGDLCL SFRHKVTGLH SGTLQVFVRK HGAHGAALWG RNGGHGWRQT QITLRGADIK SVVFKGEKRR GHTGEIGLDD VSLKKGHCS //