ID   D6RH03_HUMAN            Unreviewed;       333 AA.
AC   D6RH03;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Interleukin-6 receptor subunit beta {ECO:0000313|Ensembl:ENSP00000426224};
GN   Name=IL6ST {ECO:0000313|Ensembl:ENSP00000426224};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426224, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426224, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426224}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RH03; -.
DR   jPOST; D6RH03; -.
DR   MaxQB; D6RH03; -.
DR   PeptideAtlas; D6RH03; -.
DR   PRIDE; D6RH03; -.
DR   Ensembl; ENST00000503773; ENSP00000426224; ENSG00000134352.
DR   UCSC; uc063dsa.1; human.
DR   EuPathDB; HostDB:ENSG00000134352.19; -.
DR   HGNC; HGNC:6021; IL6ST.
DR   OpenTargets; ENSG00000134352; -.
DR   eggNOG; ENOG410IF1N; Eukaryota.
DR   eggNOG; ENOG410YNQ4; LUCA.
DR   GeneTree; ENSGT00940000159608; -.
DR   HOGENOM; HOG000171665; -.
DR   OrthoDB; 144839at2759; -.
DR   ChiTaRS; IL6ST; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000134352; Expressed in 248 organ(s), highest expression level in female gonad.
DR   ExpressionAtlas; D6RH03; baseline and differential.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010457; IgC2-like_lig-bd.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   Pfam; PF06328; Lep_receptor_Ig; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; SSF49265; 3.
DR   PROSITE; PS50853; FN3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RH03,
KW   ECO:0000213|PeptideAtlas:D6RH03};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    333       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087656.
FT   DOMAIN      224    324       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   333 AA;  37835 MW;  E87A56334BE0953B CRC64;
     MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV
     NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI
     ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT
     SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL
     KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
     CMKEDGKGYW SDWSEEASGI TYEDTLDKPL GSG
//