ID   D6RGZ6_HUMAN            Unreviewed;      1240 AA.
AC   D6RGZ6;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Versican core protein {ECO:0000313|Ensembl:ENSP00000426251};
DE   Flags: Fragment;
GN   Name=VCAN {ECO:0000313|Ensembl:ENSP00000426251};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426251, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426251, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000426251}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC016568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RGZ6; -.
DR   jPOST; D6RGZ6; -.
DR   PeptideAtlas; D6RGZ6; -.
DR   PRIDE; D6RGZ6; -.
DR   Ensembl; ENST00000513960; ENSP00000426251; ENSG00000038427.
DR   UCSC; uc063fbt.1; human.
DR   EuPathDB; HostDB:ENSG00000038427.15; -.
DR   HGNC; HGNC:2464; VCAN.
DR   OpenTargets; ENSG00000038427; -.
DR   eggNOG; ENOG410IFXS; Eukaryota.
DR   eggNOG; ENOG410ZPDG; LUCA.
DR   GeneTree; ENSGT00940000156102; -.
DR   HOGENOM; HOG000168523; -.
DR   ChiTaRS; VCAN; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000038427; Expressed in 242 organ(s), highest expression level in endometrium.
DR   ExpressionAtlas; D6RGZ6; baseline and differential.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.100.10; -; 2.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000538; Link_dom.
DR   Pfam; PF07686; V-set; 1.
DR   Pfam; PF00193; Xlink; 2.
DR   PRINTS; PR01265; LINKMODULE.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00445; LINK; 2.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF56436; SSF56436; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS01241; LINK_1; 1.
DR   PROSITE; PS50963; LINK_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RGZ6,
KW   ECO:0000213|PeptideAtlas:D6RGZ6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1240       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087381.
FT   DOMAIN       34    146       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      150    245       Link. {ECO:0000259|PROSITE:PS50963}.
FT   DOMAIN      251    347       Link. {ECO:0000259|PROSITE:PS50963}.
FT   DISULFID    196    217       {ECO:0000256|PROSITE-ProRule:PRU00323}.
FT   DISULFID    294    315       {ECO:0000256|PROSITE-ProRule:PRU00323}.
FT   NON_TER    1240   1240       {ECO:0000313|Ensembl:ENSP00000426251}.
SQ   SEQUENCE   1240 AA;  135744 MW;  DD98B91991BC44BE CRC64;
     MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE
     FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL
     LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA
     TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD
     VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS
     DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRRM SDLSVIGHPI
     DSESKEDEPC SEETDPVHDL MAEILPEFPD IIEIDLYHSE ENEEEEEECA NATDVTTTPS
     VQYINGKHLV TTVPKDPEAA EARRGQFESV APSQNFSDSS ESDTHPFVIA KTELSTAVQP
     NESTETTESL EVTWKPETYP ETSEHFSGGE PDVFPTVPFH EEFESGTAKK GAESVTERDT
     EVGHQAHEHT EPVSLFPEES SGEIAIDQES QKIAFARATE VTFGEEVEKS TSVTYTPTIV
     PSSASAYVSE EEAVTLIGNP WPDDLLSTKE SWVEATPRQV VELSGSSSIP ITEGSGEAEE
     DEDTMFTMVT DLSQRNTTDT LITLDTSRII TESFFEVPAT TIYPVSEQPS AKVVPTKFVS
     ETDTSEWISS TTVEEKKRKE EEGTTGTAST FEVYSSTQRS DQLILPFELE SPNVATSSDS
     GTRKSFMSLT TPTQSEREMT DSTPVFTETN TLENLGAQTT EHSSIHQPGV QEGLTTLPRS
     PASVFMEQGS GEAAADPETT TVSSFSLNVE YAIQAEKEVA GTLSPHVETT FSTEPTGLVL
     STVMDRVVAE NITQTSREIV ISERLGEPNY GAEIRGFSTG FPLEEDFSGD FREYSTVSHP
     IAKEETVMME GSGDAAFRDT QTSPSTVPTS VHISHISDSE GPSSTMVSTS AFPWEEFTSS
     AEGSGEQLVT VSSSVVPVLP SAVQKFSGTA SSIIDEGLGE VGTVNEIDRR STILPTAEVE
     GTKAPVEKEE VKVSGTVSTN FPQTIEPAKL WSRQEVNPVR QEIESETTSE EQIQEEKSFE
     SPQNSPATEQ TIFDSQTFTE TELKTTDYSV LTTKKTYSDD KEMKEEDTSL VNMSTPDPDA
     NGLESYTTLP EATEKSHFFL ATALVTESIP AEHVVTDSPI
//