ID   D6RGJ1_HUMAN            Unreviewed;       153 AA.
AC   D6RGJ1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   SubName: Full=Complement C1q subcomponent subunit B {ECO:0000313|Ensembl:ENSP00000426317};
DE   Flags: Fragment;
GN   Name=C1QB {ECO:0000313|Ensembl:ENSP00000426317};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426317, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426317, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426317}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL158086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RGJ1; -.
DR   SMR; D6RGJ1; -.
DR   jPOST; D6RGJ1; -.
DR   PeptideAtlas; D6RGJ1; -.
DR   PRIDE; D6RGJ1; -.
DR   Ensembl; ENST00000510260; ENSP00000426317; ENSG00000173369.
DR   UCSC; uc057ddz.1; human.
DR   EuPathDB; HostDB:ENSG00000173369.15; -.
DR   HGNC; HGNC:1242; C1QB.
DR   OpenTargets; ENSG00000173369; -.
DR   eggNOG; ENOG410IWVM; Eukaryota.
DR   eggNOG; ENOG4111MQB; LUCA.
DR   GeneTree; ENSGT00940000161091; -.
DR   HOGENOM; HOG000085653; -.
DR   ChiTaRS; C1QB; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000173369; Expressed in 208 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; D6RGJ1; baseline and differential.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR037573; Complement_C1qB.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR44403:SF2; PTHR44403:SF2; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RGJ1,
KW   ECO:0000213|PeptideAtlas:D6RGJ1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    153       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087788.
FT   DOMAIN      115    153       C1q. {ECO:0000259|PROSITE:PS50871}.
FT   NON_TER     153    153       {ECO:0000313|Ensembl:ENSP00000426317}.
SQ   SEQUENCE   153 AA;  15525 MW;  3D497DAF4F7C49AF CRC64;
     MKIPWGSIPV LMLLLLLGLI DISQAQLSCT GPPAIPGIPG IPGTPGPDGQ PGTPGIKGEK
     GLPGLAGDHG EFGEKGDPGI PGNPGKVGPK GPMGPKGGPG APGAPGPKGE SGDYKATQKI
     AFSATRTINV PLRRDQTIRF DHVITNMNNN YEP
//