ID D6RGG3_HUMAN Unreviewed; 3062 AA. AC D6RGG3; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 62. DE SubName: Full=Collagen alpha-1(XII) chain {ECO:0000313|Ensembl:ENSP00000421216}; GN Name=COL12A1 {ECO:0000313|Ensembl:ENSP00000421216}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421216, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000421216, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000421216} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL080250; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL096771; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL354664; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458206; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RGG3; -. DR IntAct; D6RGG3; 2. DR MINT; D6RGG3; -. DR EPD; D6RGG3; -. DR jPOST; D6RGG3; -. DR MaxQB; D6RGG3; -. DR PeptideAtlas; D6RGG3; -. DR PRIDE; D6RGG3; -. DR Ensembl; ENST00000483888; ENSP00000421216; ENSG00000111799. DR UCSC; uc063ppp.1; human. DR EuPathDB; HostDB:ENSG00000111799.20; -. DR HGNC; HGNC:2188; COL12A1. DR OpenTargets; ENSG00000111799; -. DR eggNOG; ENOG410IS7D; Eukaryota. DR eggNOG; ENOG4111RUM; LUCA. DR GeneTree; ENSGT00940000154923; -. DR HOGENOM; HOG000111877; -. DR ChiTaRS; COL12A1; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000111799; Expressed in 190 organ(s), highest expression level in tibia. DR ExpressionAtlas; D6RGG3; baseline and differential. DR GO; GO:0005595; C:collagen type XII trimer; IEA:InterPro. DR GO; GO:0030199; P:collagen fibril organization; IEA:InterPro. DR CDD; cd00063; FN3; 18. DR Gene3D; 2.60.40.10; -; 18. DR Gene3D; 3.40.50.410; -; 4. DR InterPro; IPR039082; COL12A1. DR InterPro; IPR008160; Collagen. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR45047:SF2; PTHR45047:SF2; 1. DR Pfam; PF01391; Collagen; 3. DR Pfam; PF00041; fn3; 18. DR Pfam; PF00092; VWA; 4. DR SMART; SM00060; FN3; 18. DR SMART; SM00210; TSPN; 1. DR SMART; SM00327; VWA; 4. DR SUPFAM; SSF49265; SSF49265; 11. DR SUPFAM; SSF49899; SSF49899; 1. DR SUPFAM; SSF53300; SSF53300; 4. DR PROSITE; PS50853; FN3; 18. DR PROSITE; PS50234; VWFA; 4. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:D6RGG3, KW ECO:0000213|MaxQB:D6RGG3, ECO:0000213|PeptideAtlas:D6RGG3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 3062 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087785. FT DOMAIN 27 117 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 140 316 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 336 426 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 440 616 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 634 722 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 725 816 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 817 905 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 907 998 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 999 1087 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1089 1179 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1199 1371 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 1387 1476 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1477 1567 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1568 1658 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1659 1754 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1755 1849 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1850 1935 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1936 2026 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2027 2117 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2118 2206 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2207 2294 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2323 2496 VWFA. {ECO:0000259|PROSITE:PS50234}. SQ SEQUENCE 3062 AA; 333202 MW; 3E075505B158789F CRC64; MRSRLPPALA ALGAALLLSS IEAEVDPPSD LNFKIIDENT VHMSWAKPVD PIVGYRITVD PTTDGPTKEF TLSASTTETL LSELVPETEY VVTITSYDEV EESVPVIGQL TIQTGSSTKP VEKKPGKTEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIAALVSAF DIGEEKTRVG VVQYSSDTRT EFNLNQYYQR DELLAAIKKI PYKGGNTMTG DAIDYLVKNT FTESAGARVG FPKVAIIITD GKSQDEVEIP ARELRNVGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVVEPPSNL IAMEVSSKYV KLNWNPSPSP VTGYKVILTP MTAGSRQHAL SVGPQTTTLS VRDLSADTEY QISVSAMKGM TSSEPISIME KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLVKSF EISPNRVQIS LVQYSRDPHT EFTLKKFTKV EDIIEAINTF PYRGGSTNTG KAMTYVREKI FVPSKGSRSN VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLSF SEVTSYGFKT NWSPAGENVF SYHITYKEAA GDDEVTVVEP ASSTSVVLSS LKPETLYLVN VTAEYEDGFS IPLAGEETTE EVKGAPRNLK VTDETTDSFK ITWTQAPGRV LRYRIIYRPV AGGESREVTT PPNQRRRTLE NLIPDTKYEV SVIPEYFSGP GTPLTGNAAT EEVRGNPRDL RVSDPTTSTM KLSWSGAPGK VKQYLVTYTP VAGGETQEVT VRGDTTNTVL QGLKEGTQYA LSVTALYASG AGDALFGEGT TLEERGSPQD LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDVDTGE KNLPEDAIHT MIENLQPETK YRISVFATYS SGEGEPLTGD ATTELSQDSK TLKVDEETEN TMRVTWKPAP GKVVNYRVVY RPHGRGKQMV AKVPPTVTST VLKRLQPQTT YDITVLPIYK MGEGKLRQGS GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVVGPYDN TVVLEELRAG TTYKVNVFGM FDGGESSPLV GQEMTTLSDT TVMPILSSGM ECLTRAEADI VLLVDGSWSI GRANFRTVRS FISRIVEVFD IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK SLLQAVANLP YKGGNTLTGM ALNFIRQQNF RTQAGMRPRA RKIGVLITDG KSQDDVEAPS KKLKDEGVEL FAIGIKNADE VELKMIATDP DDTHAYNVAD FESLSRIVDD LTINLCNSVK GPGDLEAPSN LVISERTHRS FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRMETSTV LKDLKPETEY VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA TGYILSYKPV KDTEPTRPKE VRLGPTVNDM QLTDLVPNTE YAVTVQAVLH DLTSEPVTVR EVTLPLPRPQ DLKLRDVTHS TMNVFWEPVP GKVRKYIVRY KTPEEDVKEV EVDRSETSTS LKDLFSQTLY TVSVSAVHDE GESPPVTAQE TTRPVPAPTN LKITEVTSEG FRGTWDHGAS DVSLYRITWA PFGSSDKMET ILNGDENTLV FENLNPNTIY EVSITAIYPD ESESDDLIGS ERTLPILTTQ APKSGPRNLQ VYNATSNSLT VKWDPASGRV QKYRITYQPS TGEGNEQTTT IGGRQNSVVL QKLKPDTPYT ITVSSLYPDG EGGRMTGRGK TKPLNTVRNL RVYDPSTSTL NVRWDHAEGN PRQYKLFYAP AAGGPEELVP IPGNTNYAIL RNLQPDTSYT VTVVPVYTEG DGGRTSDTGR TLMRGLARNV QVYNPTPNSL DVRWDPAPGP VLQYRVVYSP VDGTRPSESI VVPGNTRMVH LERLIPDTLY SVNLVALYSD GEGNPSPAQG RTLPRSGPRN LRVFGETTNS LSVAWDHADG PVQQYRIIYS PTVGDPIDEY TTVPGRRNNV ILQPLQPDTP YKITVIAVYE DGDGGHLTGN GRTVGLLPPQ NIHISDEWYT RFRVSWDPSP SPVLGYKIVY KPVGSNEPME AFVGEMTSYT LHNLNPSTTY DVNVYAQYDS GLSVPLTDQG TTLYLNVTDL KTYQIGWDTF CVKWSPHRAA TSYRLKLSPA DGTRGQEITV RGSETSHCFT GLSPDTDYGV TVFVQTPNLE GPGVSVKEHT TVKPTEAPTE PPTPPPPPTI PPARDVCKGA KADIVFLTDA SWSIGDDNFN KVVKFIFNTV GGFDEISPAG IQVSFVQYSD EVKSEFKLNT YNDKALALGA LQNIRYRGGN TRTGKALTFI KEKVLTWESG MRKNVPKVLV VVTDGRSQDE VKKAALVIQQ SGFSVFVVGV ADVDYNELAN IASKPSERHV FIVDDFESFE KIEDNLITFV CETATSSCPL IYLDGYTSPG FKMLEAYNLT EKNFASVQGV SLESGSFPSY SAYRIQKNAF VNQPTADLHP NGLPPSYTII LLFRLLPETP SDPFAIWQIT DRDYKPQVGV IADPSSKTLS FFNKDTRGEV QTVTFDTEEV KTLFYGSFHK VHIVVTSKSV KIYIDCYEII EKDIKEAGNI TTDGYEILGK LLKGERKSAA FQIQSFDIVC SPVWTSRDRC CDIPSRRDEG KCPAFPNSCT CTQDSVGPPG PPGPAGGPGA KGPRGERGIS GAIGPPGPRG DIGPPGPQGP PGPQGPNGLS IPGEQGRQGM KGDAGEPGLP GRTGTPGLPG PPGPMGPPGD RGFTGKDGAM GPRGPPGPGS PGVTGPSGKP GKPGDHGRPG PSGLKGEKGD RGDIASQNMM RAVARQVCEQ LISGQMNRFN QMLNQIPNDY QSSRNQPGPP GPPGPPGSAG ARGEPGPGGR PGFPGTPGMQ GPPGERGLPG EKGERGTGSS GPRGLPGPPG PQGESRTGPP GSTGSRGPPG PPGRPGNSGI RGPPGPPGYC DSSQCASIPY NGQGYPGTLL PL //