ID   D6RG08_HUMAN            Unreviewed;       175 AA.
AC   D6RG08;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Integrin alpha-2 {ECO:0000313|Ensembl:ENSP00000426489};
GN   Name=ITGA2 {ECO:0000313|Ensembl:ENSP00000426489};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426489, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426489, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000426489}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RG08; -.
DR   jPOST; D6RG08; -.
DR   MaxQB; D6RG08; -.
DR   PeptideAtlas; D6RG08; -.
DR   PRIDE; D6RG08; -.
DR   Ensembl; ENST00000503810; ENSP00000426489; ENSG00000164171.
DR   UCSC; uc063dnc.1; human.
DR   EuPathDB; HostDB:ENSG00000164171.10; -.
DR   HGNC; HGNC:6137; ITGA2.
DR   OpenTargets; ENSG00000164171; -.
DR   eggNOG; ENOG410IPB9; Eukaryota.
DR   eggNOG; ENOG4110534; LUCA.
DR   GeneTree; ENSGT00940000156303; -.
DR   HOGENOM; HOG000169179; -.
DR   ChiTaRS; ITGA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164171; Expressed in 173 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; D6RG08; baseline and differential.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   SMART; SM00191; Int_alpha; 1.
DR   PROSITE; PS51470; FG_GAP; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RG08,
KW   ECO:0000213|MaxQB:D6RG08, ECO:0000213|PeptideAtlas:D6RG08};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00504086};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087580.
FT   REPEAT       34     92       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      101    161       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
SQ   SEQUENCE   175 AA;  18710 MW;  C466F3A2216BF58A CRC64;
     MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG
     NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT
     RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQRGV NSVCQ
//