ID   D6RG04_HUMAN            Unreviewed;       199 AA.
AC   D6RG04;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Hyaluronan and proteoglycan link protein 1 {ECO:0000313|Ensembl:ENSP00000421341};
DE   Flags: Fragment;
GN   Name=HAPLN1 {ECO:0000313|Ensembl:ENSP00000421341};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421341, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421341, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421341}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR   EMBL; AC020899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RG04; -.
DR   SMR; D6RG04; -.
DR   jPOST; D6RG04; -.
DR   PeptideAtlas; D6RG04; -.
DR   PRIDE; D6RG04; -.
DR   Ensembl; ENST00000508307; ENSP00000421341; ENSG00000145681.
DR   UCSC; uc063fcc.1; human.
DR   EuPathDB; HostDB:ENSG00000145681.10; -.
DR   HGNC; HGNC:2380; HAPLN1.
DR   OpenTargets; ENSG00000145681; -.
DR   eggNOG; ENOG410IF28; Eukaryota.
DR   eggNOG; ENOG410XRS8; LUCA.
DR   GeneTree; ENSGT00940000159267; -.
DR   HOGENOM; HOG000234353; -.
DR   ChiTaRS; HAPLN1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145681; Expressed in 133 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; D6RG04; baseline and differential.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000538; Link_dom.
DR   Pfam; PF07686; V-set; 1.
DR   Pfam; PF00193; Xlink; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50963; LINK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RG04,
KW   ECO:0000213|MaxQB:D6RG04, ECO:0000213|PeptideAtlas:D6RG04};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    199       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012474785.
FT   DOMAIN       38    152       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      159    199       Link. {ECO:0000259|PROSITE:PS50963}.
FT   NON_TER     199    199       {ECO:0000313|Ensembl:ENSP00000421341}.
SQ   SEQUENCE   199 AA;  22567 MW;  F3FCAFFC46798169 CRC64;
     MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP
     CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS
     DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA
     CLDQDAVIAS FDQLYDAWR
//