ID   D6RFW5_HUMAN            Unreviewed;       483 AA.
AC   D6RFW5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 59.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT2A1 {ECO:0000313|Ensembl:ENSP00000421432};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421432, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421432, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421432}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059};
CC       Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|RuleBase:RU003718, ECO:0000256|SAAS:SAAS00846206}.
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DR   EMBL; AC093829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001288168.1; NM_001301239.1.
DR   UniGene; Hs.225950; -.
DR   ProteinModelPortal; D6RFW5; -.
DR   jPOST; D6RFW5; -.
DR   PeptideAtlas; D6RFW5; -.
DR   PRIDE; D6RFW5; -.
DR   Ensembl; ENST00000512704; ENSP00000421432; ENSG00000173610.
DR   GeneID; 10941; -.
DR   UCSC; uc010iht.4; human.
DR   CTD; 10941; -.
DR   EuPathDB; HostDB:ENSG00000173610.12; -.
DR   HGNC; HGNC:12542; UGT2A1.
DR   OpenTargets; ENSG00000173610; -.
DR   GeneTree; ENSGT00940000161344; -.
DR   HOGENOM; HOG000220831; -.
DR   GenomeRNAi; 10941; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000173610; Expressed in 28 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; D6RFW5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL        1     20       {ECO:0000256|RuleBase:RU362059}.
FT   CHAIN        21    483       UDP-glucuronosyltransferase.
FT                                {ECO:0000256|RuleBase:RU362059}.
FT                                /FTId=PRO_5005126716.
FT   TRANSMEM    447    470       Helical. {ECO:0000256|RuleBase:RU362059}.
FT   DOMAIN      310    353       UDPGT. {ECO:0000259|PROSITE:PS00375}.
SQ   SEQUENCE   483 AA;  55179 MW;  F3B3E51D23530FA2 CRC64;
     MLNNLLLFSL QISLIGTTLG GNVLIWPMEG SHWLNVKIII DELIKKEHNV TVLVASGALF
     ITPTSNPSLT FEIYKVPFGK ERIEGVIKDF VLTWLENRPS PSTIWRFYQE MAKVIKDFHM
     VSQEICDGVL KNQQLMAKLK KSKFEVLVSD PVFPCGDIVA LKLGIPFMYS LRFSPASTVE
     KHCGKVPYPP SYVPAVLSEL TDQMSFTDRI RNFISYHLQD YMFETLWKSW DSYYSKALGR
     PTTLCETMGK AEIWLIRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKVL WRYKGKKPAT
     LGNNTQLFDW IPQNDLLGHP KTKAFITHGG TNGIYEAIYH GVPMVGVPMF ADQPDNIAHM
     KAKGAAVEVN LNTMTSVDLL SALRTVINEP SYKENAMRLS RIHHDQPVKP LDRAVFWIEF
     VMRHKGAKHL RVAAHDLTWF QYHSLDVIGF LLVCVTTAIF LVIQCCLFSC QKFGKIGKKK
     KRE
//