ID   D6RFM1_HUMAN            Unreviewed;       238 AA.
AC   D6RFM1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   12-SEP-2018, entry version 48.
DE   RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN   Name=TRH {ECO:0000313|Ensembl:ENSP00000426522};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426522, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426522, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426522}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in
CC       the anterior pituitary gland and as a neurotransmitter/
CC       neuromodulator in the central and peripheral nervous systems.
CC       {ECO:0000256|PIRNR:PIRNR001795}.
CC   -!- SIMILARITY: Belongs to the TRH family.
CC       {ECO:0000256|PIRNR:PIRNR001795}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC083906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; D6RFM1; -.
DR   PRIDE; D6RFM1; -.
DR   Ensembl; ENST00000507066; ENSP00000426522; ENSG00000170893.
DR   UCSC; uc062ntn.1; human.
DR   EuPathDB; HostDB:ENSG00000170893.3; -.
DR   HGNC; HGNC:12298; TRH.
DR   OpenTargets; ENSG00000170893; -.
DR   eggNOG; ENOG410IXZK; Eukaryota.
DR   eggNOG; ENOG4111JXZ; LUCA.
DR   GeneTree; ENSGT00390000016951; -.
DR   HOGENOM; HOG000054194; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000170893; Expressed in 82 organ(s), highest expression level in endometrium.
DR   ExpressionAtlas; D6RFM1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-UniRule.
DR   GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   InterPro; IPR008857; TRH.
DR   PANTHER; PTHR17530; PTHR17530; 1.
DR   Pfam; PF05438; TRH; 1.
DR   PIRSF; PIRSF001795; TRH; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D6RFM1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|PIRNR:PIRNR001795};
KW   Signal {ECO:0000256|PIRNR:PIRNR001795}.
FT   SIGNAL        1     24       {ECO:0000256|PIRNR:PIRNR001795}.
FT   CHAIN        25    238       Pro-thyrotropin-releasing hormone.
FT                                {ECO:0000256|PIRNR:PIRNR001795}.
FT                                /FTId=PRO_5010009613.
SQ   SEQUENCE   238 AA;  26994 MW;  8CCA0CE864A98CE4 CRC64;
     MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE RLLFLRENIQ
     RLQGDQASQI FQSDWLSKRQ HPGKREEEEE EGVEEEEEEE GGAVGPHKRQ HPGRREDEAS
     WSVDVTQHKR QHPGRRSPWL AYAVPKRQHP GRRLADPKAQ RSWEEEEEEE EREEDLMPEK
     RQHPGKRALG GPCGPQGAYG QAGLLLGLLD DLSRSQGAEE KRQHPGRRAA WVREPLEE
//