ID   D6RFI7_HUMAN            Unreviewed;       182 AA.
AC   D6RFI7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Hyaluronan and proteoglycan link protein 1 {ECO:0000313|Ensembl:ENSP00000426610};
DE   Flags: Fragment;
GN   Name=HAPLN1 {ECO:0000313|Ensembl:ENSP00000426610};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426610, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426610, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426610}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR   EMBL; AC020899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RFI7; -.
DR   SMR; D6RFI7; -.
DR   jPOST; D6RFI7; -.
DR   PeptideAtlas; D6RFI7; -.
DR   PRIDE; D6RFI7; -.
DR   Ensembl; ENST00000503117; ENSP00000426610; ENSG00000145681.
DR   UCSC; uc063fcd.1; human.
DR   EuPathDB; HostDB:ENSG00000145681.10; -.
DR   HGNC; HGNC:2380; HAPLN1.
DR   OpenTargets; ENSG00000145681; -.
DR   eggNOG; ENOG410IF28; Eukaryota.
DR   eggNOG; ENOG410XRS8; LUCA.
DR   GeneTree; ENSGT00940000159267; -.
DR   HOGENOM; HOG000234353; -.
DR   ChiTaRS; HAPLN1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145681; Expressed in 133 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; D6RFI7; baseline and differential.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000538; Link_dom.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50963; LINK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RFI7,
KW   ECO:0000213|MaxQB:D6RFI7, ECO:0000213|PeptideAtlas:D6RFI7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    182       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012361656.
FT   DOMAIN       37    151       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      158    182       Link. {ECO:0000259|PROSITE:PS50963}.
FT   NON_TER     182    182       {ECO:0000313|Ensembl:ENSP00000426610}.
SQ   SEQUENCE   182 AA;  20616 MW;  6474FED675A41039 CRC64;
     MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQENGPHLL VEAEQAKVFS HRGGNVTLPC
     KFYRDPTAFG SGIHKIRIKW TKLTSDYLKE VDVFVSMGYH KKTYGGYQGR VFLKGGSDSD
     ASLVITDLTL EDYGRYKCEV IEGLEDDTVV VALDLQGVVF PYFPRLGRYN LNFHEAQQAC
     LD
//