ID   D6RF94_HUMAN            Unreviewed;       360 AA.
AC   D6RF94;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
DE   Flags: Fragment;
GN   Name=WNT8A {ECO:0000313|Ensembl:ENSP00000424809};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424809, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424809, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424809}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|RuleBase:RU003500,
CC       ECO:0000256|SAAS:SAAS00681827}.
CC   -!- SIMILARITY: Belongs to the Wnt family.
CC       {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
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DR   EMBL; AC113382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RF94; -.
DR   jPOST; D6RF94; -.
DR   PRIDE; D6RF94; -.
DR   Ensembl; ENST00000504809; ENSP00000424809; ENSG00000061492.
DR   UCSC; uc011cyj.2; human.
DR   EuPathDB; HostDB:ENSG00000061492.11; -.
DR   HGNC; HGNC:12788; WNT8A.
DR   OpenTargets; ENSG00000061492; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   eggNOG; ENOG410XQZ1; LUCA.
DR   GeneTree; ENSGT00940000157840; -.
DR   HOGENOM; HOG000039529; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000061492; Expressed in 17 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; D6RF94; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR034312; Protein_Wnt-8A/8C.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR013301; Wnt8.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   PANTHER; PTHR12027:SF92; PTHR12027:SF92; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01892; WNT8PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083909};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
KW   Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00083931};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083917}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    360       Protein Wnt. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087631.
FT   NON_TER     360    360       {ECO:0000313|Ensembl:ENSP00000424809}.
SQ   SEQUENCE   360 AA;  40046 MW;  257B216778375CEB CRC64;
     MLCCIQCLCL VSPFPTLTPC QGGPHCLIPI HLCLTFSLFG RSVNNFLITG PKAYLTYTTS
     VALGAQSGIE ECKFQFAWER WNCPENALQL STHNRLRSAT RETSFIHAIS SAGVMYIITK
     NCSMGDFENC GCDGSNNGKT GGHGWIWGGC SDNVEFGERI SKLFVDSLEK GKDARALMNL
     HNNRAGRLAV RATMKRTCKC HGISGSCSIQ TCWLQLAEFR EMGDYLKAKY DQALKIEMDK
     RQLRAGNSAE GHWVPAEAFL PSAEAELIFL EESPDYCTCN SSLGIYGTEG RECLQNSHNT
     SRWERRSCGR LCTECGLQVE ERKTEVISSC NCKFQWCCTV KCDQCRHVTM SNPAVLLGIR
//