ID   D6RF47_HUMAN            Unreviewed;       369 AA.
AC   D6RF47;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN   Name=WNT8A {ECO:0000313|Ensembl:ENSP00000426653};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426653, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426653, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426653}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|RuleBase:RU003500,
CC       ECO:0000256|SAAS:SAAS00681827}.
CC   -!- SIMILARITY: Belongs to the Wnt family.
CC       {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
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DR   EMBL; AC113382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001287868.1; NM_001300939.1.
DR   UniGene; Hs.591274; -.
DR   ProteinModelPortal; D6RF47; -.
DR   jPOST; D6RF47; -.
DR   PRIDE; D6RF47; -.
DR   Ensembl; ENST00000506684; ENSP00000426653; ENSG00000061492.
DR   GeneID; 7478; -.
DR   UCSC; uc011cyk.2; human.
DR   CTD; 7478; -.
DR   EuPathDB; HostDB:ENSG00000061492.11; -.
DR   HGNC; HGNC:12788; WNT8A.
DR   OpenTargets; ENSG00000061492; -.
DR   eggNOG; KOG3913; Eukaryota.
DR   eggNOG; ENOG410XQZ1; LUCA.
DR   GeneTree; ENSGT00940000157840; -.
DR   HOGENOM; HOG000039529; -.
DR   OMA; SAWSVNN; -.
DR   OrthoDB; 618621at2759; -.
DR   PhylomeDB; D6RF47; -.
DR   GenomeRNAi; 7478; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000061492; Expressed in 17 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; D6RF47; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR   GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR   GO; GO:0048561; P:establishment of animal organ orientation; IEA:Ensembl.
DR   GO; GO:0009949; P:polarity specification of anterior/posterior axis; IEA:Ensembl.
DR   GO; GO:0010085; P:polarity specification of proximal/distal axis; IEA:Ensembl.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR034312; Protein_Wnt-8A/8C.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR013301; Wnt8.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027; PTHR12027; 1.
DR   PANTHER; PTHR12027:SF92; PTHR12027:SF92; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01892; WNT8PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083909};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
KW   Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00083931};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
KW   ECO:0000256|SAAS:SAAS00083917}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    369       Protein Wnt. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087767.
SQ   SEQUENCE   369 AA;  40892 MW;  AF8F9A9B71878843 CRC64;
     MLCCIQCLCL VSPFPTLTPC QGGPHCLIPI HLCLTFSLFG RSVNNFLITG PKAYLTYTTS
     VALGAQSGIE ECKFQFAWER WNCPENALQL STHNRLRSAT RETSFIHAIS SAGVMYIITK
     NCSMGDFENC GCDGSNNGKT GGHGWIWGGC SDNVEFGERI SKLFVDSLEK GKDARALMNL
     HNNRAGRLAV RATMKRTCKC HGISGSCSIQ TCWLQLAEFR EMGDYLKAKY DQALKIEMDK
     RQLRAGNSAE GHWVPAEAFL PSAEAELIFL EESPDYCTCN SSLGIYGTEG RECLQNSHNT
     SRWERRSCGR LCTECGLQVE ERKTEVISSC NCKFQWCCTV KCDQCRHVVS KYYCARSPGS
     AQSLGKGSA
//