ID   D6RF20_HUMAN            Unreviewed;       145 AA.
AC   D6RF20;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Vitamin D-binding protein {ECO:0000313|Ensembl:ENSP00000426718};
DE   Flags: Fragment;
GN   Name=GC {ECO:0000313|Ensembl:ENSP00000426718};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426718, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426718, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000426718}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC024722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RF20; -.
DR   jPOST; D6RF20; -.
DR   PeptideAtlas; D6RF20; -.
DR   PRIDE; D6RF20; -.
DR   Ensembl; ENST00000506245; ENSP00000426718; ENSG00000145321.
DR   UCSC; uc062xer.1; human.
DR   EuPathDB; HostDB:ENSG00000145321.12; -.
DR   HGNC; HGNC:4187; GC.
DR   OpenTargets; ENSG00000145321; -.
DR   eggNOG; ENOG410II89; Eukaryota.
DR   eggNOG; ENOG4111PH6; LUCA.
DR   GeneTree; ENSGT00390000000113; -.
DR   ChiTaRS; GC; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000145321; Expressed in 91 organ(s), highest expression level in liver.
DR   ExpressionAtlas; D6RF20; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005499; F:vitamin D binding; IEA:InterPro.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000264; ALB/AFP/VDB.
DR   InterPro; IPR020858; Serum_albumin-like.
DR   InterPro; IPR014760; Serum_albumin_N.
DR   InterPro; IPR000213; VitD-bd.
DR   PANTHER; PTHR11385; PTHR11385; 1.
DR   PANTHER; PTHR11385:SF11; PTHR11385:SF11; 1.
DR   Pfam; PF00273; Serum_albumin; 1.
DR   PRINTS; PR00804; VITAMNDBNDNG.
DR   SMART; SM00103; ALBUMIN; 1.
DR   SUPFAM; SSF48552; SSF48552; 1.
DR   PROSITE; PS51438; ALBUMIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RF20,
KW   ECO:0000213|PeptideAtlas:D6RF20};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    145       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087627.
FT   DOMAIN       16    145       Albumin. {ECO:0000259|PROSITE:PS51438}.
FT   NON_TER     145    145       {ECO:0000313|Ensembl:ENSP00000426718}.
SQ   SEQUENCE   145 AA;  16083 MW;  2B74DA527A0013D0 CRC64;
     MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
     SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
     LCMAALKHQP QEFPTYVEPT NDEIC
//