ID   D6REX0_HUMAN            Unreviewed;       232 AA.
AC   D6REX0;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 12 {ECO:0000313|Ensembl:ENSP00000421638};
GN   Name=ADAMTS12 {ECO:0000313|Ensembl:ENSP00000421638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421638, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421638, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421638}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001311440.1; NM_001324511.1.
DR   UniGene; Hs.12680; -.
DR   ProteinModelPortal; D6REX0; -.
DR   PeptideAtlas; D6REX0; -.
DR   PRIDE; D6REX0; -.
DR   Ensembl; ENST00000515401; ENSP00000421638; ENSG00000151388.
DR   GeneID; 81792; -.
DR   UCSC; uc003jib.1; human.
DR   CTD; 81792; -.
DR   EuPathDB; HostDB:ENSG00000151388.10; -.
DR   HGNC; HGNC:14605; ADAMTS12.
DR   OpenTargets; ENSG00000151388; -.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; ENOG410XPKZ; LUCA.
DR   GeneTree; ENSGT00940000155855; -.
DR   HOGENOM; HOG000199502; -.
DR   OrthoDB; 125522at2759; -.
DR   ChiTaRS; ADAMTS12; human.
DR   GenomeRNAi; 81792; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000151388; Expressed in 110 organ(s), highest expression level in adrenal tissue.
DR   ExpressionAtlas; D6REX0; baseline and differential.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6REX0,
KW   ECO:0000213|PeptideAtlas:D6REX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    232       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087765.
FT   DOMAIN       54    195       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
SQ   SEQUENCE   232 AA;  26426 MW;  4D9BEBF1FBCB40E8 CRC64;
     MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV
     DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME
     KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK
     KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KGIVTHMSSW VEESVLFFWL FY
//