ID   D6REW6_HUMAN            Unreviewed;       105 AA.
AC   D6REW6;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Alpha-2-macroglobulin receptor-associated protein {ECO:0000313|Ensembl:ENSP00000421648};
GN   Name=LRPAP1 {ECO:0000313|Ensembl:ENSP00000421648};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421648, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421648, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421648}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AL590235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6REW6; -.
DR   jPOST; D6REW6; -.
DR   MaxQB; D6REW6; -.
DR   PeptideAtlas; D6REW6; -.
DR   PRIDE; D6REW6; -.
DR   Ensembl; ENST00000515119; ENSP00000421648; ENSG00000163956.
DR   UCSC; uc062uvg.1; human.
DR   EuPathDB; HostDB:ENSG00000163956.10; -.
DR   HGNC; HGNC:6701; LRPAP1.
DR   OpenTargets; ENSG00000163956; -.
DR   eggNOG; KOG3956; Eukaryota.
DR   eggNOG; ENOG410YJFP; LUCA.
DR   GeneTree; ENSGT00390000004855; -.
DR   ChiTaRS; LRPAP1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000163956; Expressed in 233 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; D6REW6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:InterPro.
DR   GO; GO:0048019; F:receptor antagonist activity; IEA:InterPro.
DR   Gene3D; 1.20.81.10; -; 1.
DR   InterPro; IPR038003; A2-macroglobuin_RAP.
DR   InterPro; IPR009066; MG_RAP_rcpt_1.
DR   InterPro; IPR036744; RAP_sf.
DR   PANTHER; PTHR16560; PTHR16560; 1.
DR   Pfam; PF06400; Alpha-2-MRAP_N; 1.
DR   SUPFAM; SSF47045; SSF47045; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6REW6,
KW   ECO:0000213|MaxQB:D6REW6, ECO:0000213|PeptideAtlas:D6REW6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    105       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087358.
FT   DOMAIN       20     72       Alpha-2-MRAP_N.
FT                                {ECO:0000259|Pfam:PF06400}.
SQ   SEQUENCE   105 AA;  12016 MW;  04A9F19B4B15F154 CRC64;
     MAPRRVRSFL RGLPALLLLL LFLGPWPAAS HGGKYSREKN QPKPSPKRES GEEFRMEKLN
     QLWEKAQRNL PVASLLRGQF LAVSWSVLLV AHRLLPFVRS CIFLP
//