ID D6RER2_HUMAN Unreviewed; 575 AA. AC D6RER2; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 65. DE SubName: Full=Cadherin-18 {ECO:0000313|Ensembl:ENSP00000424931}; GN Name=CDH18 {ECO:0000313|Ensembl:ENSP00000424931}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424931, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000424931, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000424931} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01075634}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC025173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC093221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC118463; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF454884; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457863; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001278886.1; NM_001291957.1. DR RefSeq; XP_011512232.1; XM_011513930.2. DR RefSeq; XP_016864424.1; XM_017008935.1. DR RefSeq; XP_016864425.1; XM_017008936.1. DR RefSeq; XP_016864426.1; XM_017008937.1. DR RefSeq; XP_016864427.1; XM_017008938.1. DR UniGene; Hs.317632; -. DR UniGene; Hs.590304; -. DR ProteinModelPortal; D6RER2; -. DR jPOST; D6RER2; -. DR PeptideAtlas; D6RER2; -. DR PRIDE; D6RER2; -. DR Ensembl; ENST00000506372; ENSP00000424931; ENSG00000145526. DR GeneID; 1016; -. DR UCSC; uc021xwu.2; human. DR CTD; 1016; -. DR EuPathDB; HostDB:ENSG00000145526.11; -. DR HGNC; HGNC:1757; CDH18. DR OpenTargets; ENSG00000145526; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000157512; -. DR HOGENOM; HOG000231252; -. DR OrthoDB; 240489at2759; -. DR ChiTaRS; CDH18; human. DR GenomeRNAi; 1016; -. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000145526; Expressed in 102 organ(s), highest expression level in middle temporal gyrus. DR ExpressionAtlas; D6RER2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR InterPro; IPR039808; Cadherin. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR PANTHER; PTHR24027; PTHR24027; 1. DR Pfam; PF00028; Cadherin; 4. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 4. DR SUPFAM; SSF49313; SSF49313; 5. DR PROSITE; PS00232; CADHERIN_1; 2. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Cell adhesion {ECO:0000256|SAAS:SAAS01075623}; KW Cell membrane {ECO:0000256|SAAS:SAAS01075618}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAAS:SAAS01075618}; KW Metal-binding {ECO:0000256|SAAS:SAAS01075609}; KW Proteomics identification {ECO:0000213|PeptideAtlas:D6RER2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 575 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087413. FT DOMAIN 76 157 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 181 266 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 290 382 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 405 486 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 575 AA; 63748 MW; 4E285F073DFC606B CRC64; MKITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVMRNQTKH IEGETEVHHR PKRGWVWNQF FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI FIIDDTTGDI HSTKSLDREQ KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ VTATDADDPT YGNSARVVYS ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD MAGQVGGLSG STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN ADMTYSIING DGMGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA NTHLDFRFSH LGPFKDATML KIIVGDVDEP PLFSMPSYLM EVYENAKIGT VVGTVLAQDP DSTNSLVRYF INYNVEDDRF FNIDANTGTI RTTKVLDREE TPWYNITVTA SEIDNPDLLS HVTVGIRVLD VNDNPPELAR EYDIIVCENS KPGQVIHTIS ATDKDDFANG PRFNFFLDER LPVNPNFTLK DNEAAAAPSP SGFVHAREMG VCGPAMQKPS CPRLV //