ID   D6REC9_HUMAN            Unreviewed;       166 AA.
AC   D6REC9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 72.
DE   SubName: Full=THO complex subunit 3 {ECO:0000313|Ensembl:ENSP00000425039};
GN   Name=THOC3 {ECO:0000313|Ensembl:ENSP00000425039};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425039, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425039, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000425039}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC138965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6REC9; -.
DR   jPOST; D6REC9; -.
DR   MaxQB; D6REC9; -.
DR   PeptideAtlas; D6REC9; -.
DR   PRIDE; D6REC9; -.
DR   Ensembl; ENST00000514861; ENSP00000425039; ENSG00000051596.
DR   UCSC; uc063jwf.1; human.
DR   EuPathDB; HostDB:ENSG00000051596.9; -.
DR   HGNC; HGNC:19072; THOC3.
DR   OpenTargets; ENSG00000051596; -.
DR   eggNOG; KOG1407; Eukaryota.
DR   eggNOG; ENOG410XPZJ; LUCA.
DR   GeneTree; ENSGT00940000158129; -.
DR   SignaLink; D6REC9; -.
DR   ChiTaRS; THOC3; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000051596; Expressed in 93 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; D6REC9; baseline and differential.
DR   GO; GO:0000346; C:transcription export complex; IEA:InterPro.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR040132; Tex1/THOC3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22839; PTHR22839; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6REC9,
KW   ECO:0000213|MaxQB:D6REC9, ECO:0000213|PeptideAtlas:D6REC9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00723881};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221,
KW   ECO:0000256|SAAS:SAAS00723873}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    166       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087556.
FT   DOMAIN       35    118       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
FT   REPEAT       35     69       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
SQ   SEQUENCE   166 AA;  18365 MW;  B68910BB5AE7E70E CRC64;
     MAWLCGSLPV VVAVTAMETA ARQECYPELK PVQSINAHPS NCICIKFDPM GKYFATGSAD
     ALVSLWDVDE LVCVRCFSRL DWPVRTLSFS HDGKMLASAS EDHFIDIAEV ETGDKLWEVQ
     CESPTFTVAW HPKRPLLAFA CDDKDGKYDS SREAGTVKLF GLPNDS
//