ID   D6RE86_HUMAN            Unreviewed;       178 AA.
AC   D6RE86;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Ceruloplasmin {ECO:0000313|Ensembl:ENSP00000426888};
DE   Flags: Fragment;
GN   Name=CP {ECO:0000313|Ensembl:ENSP00000426888};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426888, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426888, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426888}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC093001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; D6RE86; -.
DR   PeptideAtlas; D6RE86; -.
DR   PRIDE; D6RE86; -.
DR   Ensembl; ENST00000455472; ENSP00000426888; ENSG00000047457.
DR   UCSC; uc062owr.1; human.
DR   EuPathDB; HostDB:ENSG00000047457.13; -.
DR   HGNC; HGNC:2295; CP.
DR   OpenTargets; ENSG00000047457; -.
DR   GeneTree; ENSGT00940000155866; -.
DR   ChiTaRS; CP; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000047457; Expressed in 185 organ(s), highest expression level in liver.
DR   ExpressionAtlas; D6RE86; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004322; F:ferroxidase activity; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR   InterPro; IPR027150; CP.
DR   InterPro; IPR011707; Cu-oxidase_3.
DR   InterPro; IPR008972; Cupredoxin.
DR   PANTHER; PTHR44048:SF5; PTHR44048:SF5; 2.
DR   Pfam; PF07732; Cu-oxidase_3; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RE86,
KW   ECO:0000213|PeptideAtlas:D6RE86};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    178       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413423.
FT   DOMAIN      132    169       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07732}.
FT   NON_TER     178    178       {ECO:0000313|Ensembl:ENSP00000426888}.
SQ   SEQUENCE   178 AA;  20762 MW;  0F02B236946304B5 CRC64;
     MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTG FQNKWYSEDV
     TISRPNDQEE ITAQILTKKL DNKEHSTLRE HSNIYLQNGP DRIGRLYKKA LYLQYTDETF
     RTTIEKPVWL GFLGPIIKAE TGDKVYVHLK NLASRPYTFH SHGITYYKEH EGAIYPDN
//