ID   D6RDX1_HUMAN            Unreviewed;       288 AA.
AC   D6RDX1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Vesicular integral-membrane protein VIP36 {ECO:0000313|Ensembl:ENSP00000425229};
DE   Flags: Fragment;
GN   Name=LMAN2 {ECO:0000313|Ensembl:ENSP00000425229};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425229, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425229, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000425229}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC146507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RDX1; -.
DR   jPOST; D6RDX1; -.
DR   MaxQB; D6RDX1; -.
DR   PeptideAtlas; D6RDX1; -.
DR   PRIDE; D6RDX1; -.
DR   Ensembl; ENST00000502560; ENSP00000425229; ENSG00000169223.
DR   UCSC; uc063kcz.1; human.
DR   EuPathDB; HostDB:ENSG00000169223.14; -.
DR   HGNC; HGNC:16986; LMAN2.
DR   OpenTargets; ENSG00000169223; -.
DR   eggNOG; KOG3839; Eukaryota.
DR   eggNOG; ENOG410YH8V; LUCA.
DR   GeneTree; ENSGT00940000158355; -.
DR   HOGENOM; HOG000164540; -.
DR   ChiTaRS; LMAN2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000169223; Expressed in 230 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; D6RDX1; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   CDD; cd06901; lectin_VIP36_VIPL; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR005052; Lectin_leg.
DR   InterPro; IPR035664; VIP36_lectin.
DR   Pfam; PF03388; Lectin_leg-like; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51328; L_LECTIN_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:D6RDX1,
KW   ECO:0000213|MaxQB:D6RDX1, ECO:0000213|PeptideAtlas:D6RDX1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     44       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        45    288       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087348.
FT   DOMAIN       52    269       L-type lectin-like.
FT                                {ECO:0000259|PROSITE:PS51328}.
FT   NON_TER     288    288       {ECO:0000313|Ensembl:ENSP00000425229}.
SQ   SEQUENCE   288 AA;  32707 MW;  02EBD5BBD521CAD3 CRC64;
     MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL
     IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV
     HGTGKKNLHG DGIALWYTRD RLVPDNFHGL AIFLDTYPND ETTERVFPYI SVMVNNGSLS
     YDHSKDGRWT ELAGCTADFR NRDHDTFLAV RYSRGRLTVM TDLEDKNEWK NCIDITGVRL
     PTGYYFGASA GTGDLSDNHD IISMKLFQLM VEHTPDEESI DWTKIEPS
//