ID   D6RDV5_HUMAN            Unreviewed;       201 AA.
AC   D6RDV5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Ephrin-A5 {ECO:0000313|Ensembl:ENSP00000426989};
GN   Name=EFNA5 {ECO:0000313|Ensembl:ENSP00000426989};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426989, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426989, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426989}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ephrin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00884, ECO:0000256|RuleBase:RU004375}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00884}.
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DR   EMBL; AC008796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006714628.1; XM_006714565.2.
DR   UniGene; Hs.288741; -.
DR   ProteinModelPortal; D6RDV5; -.
DR   SMR; D6RDV5; -.
DR   MaxQB; D6RDV5; -.
DR   PeptideAtlas; D6RDV5; -.
DR   PRIDE; D6RDV5; -.
DR   Ensembl; ENST00000509503; ENSP00000426989; ENSG00000184349.
DR   GeneID; 1946; -.
DR   UCSC; uc063fvw.1; human.
DR   CTD; 1946; -.
DR   EuPathDB; HostDB:ENSG00000184349.12; -.
DR   HGNC; HGNC:3225; EFNA5.
DR   OpenTargets; ENSG00000184349; -.
DR   GeneTree; ENSGT00940000157299; -.
DR   HOGENOM; HOG000234373; -.
DR   OrthoDB; 1094764at2759; -.
DR   ChiTaRS; EFNA5; human.
DR   GenomeRNAi; 1946; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000184349; Expressed in 214 organ(s), highest expression level in hair follicle.
DR   ExpressionAtlas; D6RDV5; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046875; F:ephrin receptor binding; IEA:InterPro.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd10425; Ephrin-A_Ectodomain; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR031328; Ephrin.
DR   InterPro; IPR034252; Ephrin-A_Ecto.
DR   InterPro; IPR019765; Ephrin_CS.
DR   InterPro; IPR001799; Ephrin_RBD.
DR   PANTHER; PTHR11304; PTHR11304; 2.
DR   Pfam; PF00812; Ephrin; 1.
DR   PRINTS; PR01347; EPHRIN.
DR   ProDom; PD002533; Ephrin; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   PROSITE; PS01299; EPHRIN_RBD_1; 1.
DR   PROSITE; PS51551; EPHRIN_RBD_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00884};
KW   Membrane {ECO:0000256|RuleBase:RU004375};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RDV5,
KW   ECO:0000213|PeptideAtlas:D6RDV5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    201       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087346.
FT   DOMAIN       29    162       Ephrin RBD.
FT                                {ECO:0000259|PROSITE:PS51551}.
FT   DISULFID     62    102       {ECO:0000256|PROSITE-ProRule:PRU00884}.
SQ   SEQUENCE   201 AA;  23296 MW;  1AF418B698BAEAA4 CRC64;
     MLHVEMLTLV FLVLWMCVFS QDPGSKAVAD RYAVYWNSSN PRFQRGDYHI DVCINDYLDV
     FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW ECNRPHSPNG PLKFSEKFQL
     FTPFSLGFEF RPGREYFYIS SAIPDNGRRS CLKLKVFVRP TNDTVHESAE PSRGENAAQT
     PRIPSRLLAI LLFLLAMLLT L
//