ID   D6RD79_HUMAN            Unreviewed;       129 AA.
AC   D6RD79;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   13-FEB-2019, entry version 46.
DE   RecName: Full=GDT1 family protein {ECO:0000256|RuleBase:RU365102};
GN   Name=TMEM165 {ECO:0000313|Ensembl:ENSP00000425449};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425449, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425449, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425449}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU365102};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365102}.
CC   -!- SIMILARITY: Belongs to the GDT1 family.
CC       {ECO:0000256|RuleBase:RU365102}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU365102}.
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DR   EMBL; AC069200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RD79; -.
DR   jPOST; D6RD79; -.
DR   MaxQB; D6RD79; -.
DR   PeptideAtlas; D6RD79; -.
DR   PRIDE; D6RD79; -.
DR   Ensembl; ENST00000506198; ENSP00000425449; ENSG00000134851.
DR   UCSC; uc062wsu.1; human.
DR   EuPathDB; HostDB:ENSG00000134851.12; -.
DR   HGNC; HGNC:30760; TMEM165.
DR   OpenTargets; ENSG00000134851; -.
DR   eggNOG; KOG2881; Eukaryota.
DR   eggNOG; COG2119; LUCA.
DR   GeneTree; ENSGT00390000005261; -.
DR   ChiTaRS; TMEM165; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000134851; Expressed in 218 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; D6RD79; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001727; Gdt1.
DR   PANTHER; PTHR12608; PTHR12608; 1.
DR   Pfam; PF01169; UPF0016; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU365102};
KW   Proteomics identification {ECO:0000213|EPD:D6RD79,
KW   ECO:0000213|MaxQB:D6RD79, ECO:0000213|PeptideAtlas:D6RD79};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU365102};
KW   Transmembrane {ECO:0000256|RuleBase:RU365102};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365102}.
FT   SIGNAL        1     33       {ECO:0000256|RuleBase:RU365102}.
FT   CHAIN        34    129       GDT1 family protein.
FT                                {ECO:0000256|RuleBase:RU365102}.
FT                                /FTId=PRO_5017496304.
FT   TRANSMEM     72     92       Helical. {ECO:0000256|RuleBase:RU365102}.
FT   TRANSMEM    104    123       Helical. {ECO:0000256|RuleBase:RU365102}.
SQ   SEQUENCE   129 AA;  13276 MW;  F16D95799655DA44 CRC64;
     MAAAAPGNGR ASAPRLLLLF LVPLLWAPAA VRAGPDEDLS HRNKEPPAPA QQLQPQPVAV
     QGPEPARVED PYGVAVGGTV GHCLCTGLAV IGGRMIAQKI SVRTVTIIGG IVFLAFAFSA
     LFISPDSGF
//