ID D6RCS5_HUMAN Unreviewed; 66 AA. AC D6RCS5; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 05-DEC-2018, entry version 59. DE SubName: Full=Gamma-aminobutyric acid A receptor alpha 2 isoform 2 {ECO:0000313|EMBL:ALQ33540.1}; DE SubName: Full=Gamma-aminobutyric acid receptor subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000425526}; GN Name=GABRA2 {ECO:0000313|EMBL:ALQ33540.1, GN ECO:0000313|Ensembl:ENSP00000425526}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425526, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000425526, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000425526} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000421639} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSP00000486333} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. RN [5] {ECO:0000313|EMBL:ALQ33540.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by RT Alternative Splicing."; RL Cell 164:805-817(2016). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC084352; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC093745; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC095060; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC104072; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU178082; ALQ33540.1; -; mRNA. DR UniGene; Hs.116250; -. DR UniGene; Hs.48372; -. DR SMR; D6RCS5; -. DR PeptideAtlas; D6RCS5; -. DR PRIDE; D6RCS5; -. DR Ensembl; ENST00000513005; ENSP00000421639; ENSG00000151834. DR Ensembl; ENST00000514193; ENSP00000425526; ENSG00000151834. DR Ensembl; ENST00000630416; ENSP00000486333; ENSG00000151834. DR UCSC; uc062wil.1; human. DR EuPathDB; HostDB:ENSG00000151834.15; -. DR HGNC; HGNC:4076; GABRA2. DR OpenTargets; ENSG00000151834; -. DR eggNOG; KOG3642; Eukaryota. DR eggNOG; ENOG410XNQG; LUCA. DR GeneTree; ENSGT00940000157266; -. DR ChiTaRS; GABRA2; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000151834; Expressed in 133 organ(s), highest expression level in amygdala. DR ExpressionAtlas; D6RCS5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR GO; GO:0005216; F:ion channel activity; IEA:InterPro. DR GO; GO:0006821; P:chloride transport; IEA:InterPro. DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. DR InterPro; IPR005432; GABBAa2_rcpt. DR InterPro; IPR006201; Neur_channel. DR PANTHER; PTHR18945; PTHR18945; 1. DR PANTHER; PTHR18945:SF218; PTHR18945:SF218; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Receptor {ECO:0000313|EMBL:ALQ33540.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 66 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014088022. SQ SEQUENCE 66 AA; 7759 MW; 085748A8B17F0C8F CRC64; MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG LGGIYN //