ID   D6RC67_HUMAN            Unreviewed;       102 AA.
AC   D6RC67;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 61.
DE   RecName: Full=Prolactin receptor {ECO:0000256|RuleBase:RU365035};
DE            Short=PRL-R {ECO:0000256|RuleBase:RU365035};
DE   Flags: Fragment;
GN   Name=PRLR {ECO:0000256|RuleBase:RU365035,
GN   ECO:0000313|Ensembl:ENSP00000422385};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422385, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422385, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422385}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: This is a receptor for the anterior pituitary hormone
CC       prolactin. {ECO:0000256|RuleBase:RU365035}.
CC   -!- SUBUNIT: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and
CC       this interaction is prolactin-dependent.
CC       {ECO:0000256|RuleBase:RU365035}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU365035};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU365035}.
CC   -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC       folding and thereby efficient intracellular transport and cell-
CC       surface receptor binding. {ECO:0000256|RuleBase:RU365035}.
CC   -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC       activation. {ECO:0000256|RuleBase:RU365035}.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC       subfamily. {ECO:0000256|RuleBase:RU365035}.
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DR   EMBL; AC010368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RC67; -.
DR   PeptideAtlas; D6RC67; -.
DR   PRIDE; D6RC67; -.
DR   Ensembl; ENST00000503330; ENSP00000422385; ENSG00000113494.
DR   UCSC; uc063cxx.1; human.
DR   EuPathDB; HostDB:ENSG00000113494.16; -.
DR   HGNC; HGNC:9446; PRLR.
DR   OpenTargets; ENSG00000113494; -.
DR   eggNOG; ENOG410IUSW; Eukaryota.
DR   eggNOG; ENOG410XRJS; LUCA.
DR   GeneTree; ENSGT00940000154851; -.
DR   HOGENOM; HOG000213512; -.
DR   ChiTaRS; PRLR; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113494; Expressed in 140 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; D6RC67; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004925; F:prolactin receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR033230; PRLR.
DR   PANTHER; PTHR23036:SF86; PTHR23036:SF86; 1.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|RuleBase:RU365035};
KW   Metal-binding {ECO:0000256|RuleBase:RU365035};
KW   Receptor {ECO:0000256|RuleBase:RU365035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU365035};
KW   Zinc {ECO:0000256|RuleBase:RU365035}.
FT   SIGNAL        1     24       {ECO:0000256|RuleBase:RU365035}.
FT   CHAIN        25    102       Prolactin receptor.
FT                                {ECO:0000256|RuleBase:RU365035}.
FT                                /FTId=PRO_5015373791.
FT   DOMAIN       25     99       EpoR_lig-bind.
FT                                {ECO:0000259|Pfam:PF09067}.
FT   NON_TER     102    102       {ECO:0000313|Ensembl:ENSP00000422385}.
SQ   SEQUENCE   102 AA;  11673 MW;  07010A0712584251 CRC64;
     MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY
     SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MM
//