ID   D6RC51_HUMAN            Unreviewed;       119 AA.
AC   D6RC51;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   12-SEP-2018, entry version 50.
DE   SubName: Full=Serine protease inhibitor Kazal-type 2 {ECO:0000313|Ensembl:ENSP00000423858};
GN   Name=SPINK2 {ECO:0000313|Ensembl:ENSP00000423858};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423858, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423858, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423858}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC022483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001258649.1; NM_001271720.1.
DR   UniGene; Hs.98243; -.
DR   ProteinModelPortal; D6RC51; -.
DR   MEROPS; I01.012; -.
DR   PeptideAtlas; D6RC51; -.
DR   PRIDE; D6RC51; -.
DR   Ensembl; ENST00000504762; ENSP00000423858; ENSG00000128040.
DR   GeneID; 6691; -.
DR   UCSC; uc031sen.2; human.
DR   CTD; 6691; -.
DR   EuPathDB; HostDB:ENSG00000128040.10; -.
DR   HGNC; HGNC:11245; SPINK2.
DR   OpenTargets; ENSG00000128040; -.
DR   GeneTree; ENSGT00530000064285; -.
DR   HOGENOM; HOG000090244; -.
DR   GenomeRNAi; 6691; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000128040; Expressed in 109 organ(s), highest expression level in corpus epididymis.
DR   ExpressionAtlas; D6RC51; baseline and differential.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RC51,
KW   ECO:0000213|PeptideAtlas:D6RC51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    119       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087590.
FT   DOMAIN       65    119       Kazal-like.
FT                                {ECO:0000259|PROSITE:PS51465}.
SQ   SEQUENCE   119 AA;  12455 MW;  E32B1E6811C3ADFF CRC64;
     MALSVLRLAL LLLAVTFAGS ARSGPGERGP PEKSGFGSQT GGGPCPAPGG LGDASLIPQF
     GLFSKYRTPN CSQYRLPGCP RHFNPVCGSD MSTYANECTL CMKIREGGHN IKIIRNGPC
//