ID   D6RBU5_HUMAN            Unreviewed;       486 AA.
AC   D6RBU5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSP00000422524};
GN   Name=NFASC {ECO:0000313|Ensembl:ENSP00000422524};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422524, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422524, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422524}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC096675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RBU5; -.
DR   jPOST; D6RBU5; -.
DR   PeptideAtlas; D6RBU5; -.
DR   PRIDE; D6RBU5; -.
DR   Ensembl; ENST00000504476; ENSP00000422524; ENSG00000163531.
DR   UCSC; uc057orq.1; human.
DR   EuPathDB; HostDB:ENSG00000163531.15; -.
DR   HGNC; HGNC:29866; NFASC.
DR   OpenTargets; ENSG00000163531; -.
DR   eggNOG; KOG3513; Eukaryota.
DR   eggNOG; ENOG410XSVG; LUCA.
DR   GeneTree; ENSGT00940000157024; -.
DR   HOGENOM; HOG000231380; -.
DR   ChiTaRS; NFASC; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000163531; Expressed in 203 organ(s), highest expression level in brain.
DR   ExpressionAtlas; D6RBU5; baseline and differential.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0042552; P:myelination; IEA:InterPro.
DR   GO; GO:0007422; P:peripheral nervous system development; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:InterPro.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR026965; NFASC.
DR   PANTHER; PTHR43951:SF4; PTHR43951:SF4; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RBU5,
KW   ECO:0000213|PeptideAtlas:D6RBU5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    486       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087587.
FT   DOMAIN       41    137       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      143    230       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      261    349       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      354    441       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   486 AA;  54477 MW;  3A3265F2A5500586 CRC64;
     MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL
     IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA
     RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM
     EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTNHPYN
     DSSLRNHPDM YSARGVAERT PSFMYPQGTA SSQMVLRGMD LLLECIASGV PTPDIAWYKK
     GGDLPSDKAK FENFNKALRI TNVSEEDSGE YFCLASNKMG SIRHTISVRV KAAPYWLDEP
     KNLILAPGED GRLVCRANGN PKPTVQWMVN GEPLQSAPPN PNREVAGDTI IFRDTQISSR
     AVYQCNTSNE HGYLLANAFV SVLDVPPRML SPRNQLIRVI LYNRTRLDCP FFGSPIPTLR
     CPHGLS
//