ID   D6RBS1_HUMAN            Unreviewed;       258 AA.
AC   D6RBS1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Hyaluronan and proteoglycan link protein 1 {ECO:0000313|Ensembl:ENSP00000422592};
DE   Flags: Fragment;
GN   Name=HAPLN1 {ECO:0000313|Ensembl:ENSP00000422592};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422592, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422592, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422592}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR   EMBL; AC020899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RBS1; -.
DR   jPOST; D6RBS1; -.
DR   MaxQB; D6RBS1; -.
DR   PeptideAtlas; D6RBS1; -.
DR   PRIDE; D6RBS1; -.
DR   Ensembl; ENST00000510978; ENSP00000422592; ENSG00000145681.
DR   UCSC; uc063fcb.1; human.
DR   EuPathDB; HostDB:ENSG00000145681.10; -.
DR   HGNC; HGNC:2380; HAPLN1.
DR   OpenTargets; ENSG00000145681; -.
DR   eggNOG; ENOG410IF28; Eukaryota.
DR   eggNOG; ENOG410XRS8; LUCA.
DR   GeneTree; ENSGT00940000159267; -.
DR   HOGENOM; HOG000234353; -.
DR   ChiTaRS; HAPLN1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145681; Expressed in 133 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; D6RBS1; baseline and differential.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000538; Link_dom.
DR   Pfam; PF07686; V-set; 1.
DR   Pfam; PF00193; Xlink; 1.
DR   PRINTS; PR01265; LINKMODULE.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SMART; SM00445; LINK; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS01241; LINK_1; 1.
DR   PROSITE; PS50963; LINK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW   Proteomics identification {ECO:0000213|EPD:D6RBS1,
KW   ECO:0000213|MaxQB:D6RBS1, ECO:0000213|PeptideAtlas:D6RBS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    258       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012519678.
FT   DOMAIN       38    152       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      159    254       Link. {ECO:0000259|PROSITE:PS50963}.
FT   DISULFID    205    226       {ECO:0000256|PROSITE-ProRule:PRU00323}.
FT   NON_TER     258    258       {ECO:0000313|Ensembl:ENSP00000422592}.
SQ   SEQUENCE   258 AA;  29201 MW;  9320A479697906EA CRC64;
     MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP
     CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS
     DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA
     CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF
     WDKDKSRYDV FCFTSNFN
//