ID   D6RBR4_HUMAN            Unreviewed;       153 AA.
AC   D6RBR4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   05-DEC-2018, entry version 57.
DE   SubName: Full=Arylsulfatase K {ECO:0000313|Ensembl:ENSP00000422608};
GN   Name=ARSK {ECO:0000313|Ensembl:ENSP00000422608};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422608, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422608, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422608}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RBR4; -.
DR   MaxQB; D6RBR4; -.
DR   PeptideAtlas; D6RBR4; -.
DR   PRIDE; D6RBR4; -.
DR   Ensembl; ENST00000513814; ENSP00000422608; ENSG00000164291.
DR   UCSC; uc063fmi.1; human.
DR   EuPathDB; HostDB:ENSG00000164291.16; -.
DR   HGNC; HGNC:25239; ARSK.
DR   OpenTargets; ENSG00000164291; -.
DR   eggNOG; KOG3731; Eukaryota.
DR   eggNOG; COG3119; LUCA.
DR   GeneTree; ENSGT00940000158982; -.
DR   HOGENOM; HOG000169156; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164291; Expressed in 196 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; D6RBR4; baseline and differential.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RBR4,
KW   ECO:0000213|PeptideAtlas:D6RBR4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    153       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013243328.
FT   DOMAIN       32    130       Sulfatase. {ECO:0000259|Pfam:PF00884}.
SQ   SEQUENCE   153 AA;  17145 MW;  35337EEC69AADFBD CRC64;
     MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP GSQVVKLPFI
     NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN NFKGLDPNYT TWMDVMERHG
     YRTQKFGKLD YTSGHHSIRH SERGSTNQRS EKV
//