ID D6RBJ7_HUMAN Unreviewed; 348 AA. AC D6RBJ7; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 16-JAN-2019, entry version 53. DE SubName: Full=Vitamin D-binding protein {ECO:0000313|Ensembl:ENSP00000422664}; GN Name=GC {ECO:0000313|Ensembl:ENSP00000422664}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422664, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000422664, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000422664} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC024722; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457777; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D6RBJ7; -. DR jPOST; D6RBJ7; -. DR PeptideAtlas; D6RBJ7; -. DR PRIDE; D6RBJ7; -. DR Ensembl; ENST00000509740; ENSP00000422664; ENSG00000145321. DR UCSC; uc062xen.1; human. DR EuPathDB; HostDB:ENSG00000145321.12; -. DR HGNC; HGNC:4187; GC. DR OpenTargets; ENSG00000145321; -. DR eggNOG; ENOG410II89; Eukaryota. DR eggNOG; ENOG4111PH6; LUCA. DR GeneTree; ENSGT00390000000113; -. DR HOGENOM; HOG000140946; -. DR ChiTaRS; GC; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000145321; Expressed in 91 organ(s), highest expression level in liver. DR ExpressionAtlas; D6RBJ7; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:InterPro. DR GO; GO:0005499; F:vitamin D binding; IEA:InterPro. DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro. DR CDD; cd00015; ALBUMIN; 1. DR InterPro; IPR000264; ALB/AFP/VDB. DR InterPro; IPR020858; Serum_albumin-like. DR InterPro; IPR020857; Serum_albumin_CS. DR InterPro; IPR014760; Serum_albumin_N. DR InterPro; IPR000213; VitD-bd. DR PANTHER; PTHR11385; PTHR11385; 1. DR PANTHER; PTHR11385:SF11; PTHR11385:SF11; 1. DR Pfam; PF00273; Serum_albumin; 2. DR PRINTS; PR00802; SERUMALBUMIN. DR PRINTS; PR00804; VITAMNDBNDNG. DR SMART; SM00103; ALBUMIN; 2. DR SUPFAM; SSF48552; SSF48552; 2. DR PROSITE; PS00212; ALBUMIN_1; 1. DR PROSITE; PS51438; ALBUMIN_2; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:D6RBJ7, KW ECO:0000213|MaxQB:D6RBJ7, ECO:0000213|PeptideAtlas:D6RBJ7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 348 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003087367. FT DOMAIN 16 208 Albumin. {ECO:0000259|PROSITE:PS51438}. FT DOMAIN 209 348 Albumin. {ECO:0000259|PROSITE:PS51438}. SQ SEQUENCE 348 AA; 38797 MW; F576A1743A83480C CRC64; MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKALY //