ID   D6RBG2_HUMAN            Unreviewed;       150 AA.
AC   D6RBG2;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Protocadherin-1 {ECO:0000313|Ensembl:ENSP00000424163};
DE   Flags: Fragment;
GN   Name=PCDH1 {ECO:0000313|Ensembl:ENSP00000424163};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424163, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424163, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000424163}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC094107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; D6RBG2; -.
DR   EPD; D6RBG2; -.
DR   jPOST; D6RBG2; -.
DR   MaxQB; D6RBG2; -.
DR   PeptideAtlas; D6RBG2; -.
DR   PRIDE; D6RBG2; -.
DR   Ensembl; ENST00000514773; ENSP00000424163; ENSG00000156453.
DR   UCSC; uc063ida.1; human.
DR   EuPathDB; HostDB:ENSG00000156453.13; -.
DR   HGNC; HGNC:8655; PCDH1.
DR   OpenTargets; ENSG00000156453; -.
DR   eggNOG; ENOG410II7Q; Eukaryota.
DR   eggNOG; ENOG410XPHP; LUCA.
DR   GeneTree; ENSGT00940000155521; -.
DR   ChiTaRS; PCDH1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000156453; Expressed in 214 organ(s), highest expression level in lower esophagus mucosa.
DR   ExpressionAtlas; D6RBG2; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   SUPFAM; SSF49313; SSF49313; 1.
DR   PROSITE; PS00232; CADHERIN_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:D6RBG2,
KW   ECO:0000213|PeptideAtlas:D6RBG2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36    150       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003087366.
FT   DOMAIN       38    118       Cadherin_2. {ECO:0000259|Pfam:PF08266}.
FT   NON_TER     150    150       {ECO:0000313|Ensembl:ENSP00000424163}.
SQ   SEQUENCE   150 AA;  16324 MW;  84957D70141EBE75 CRC64;
     MEHLRHSPGP GGQRLLLPSM LLALLLLLAP SPGHATRVVY KVPEEQPPNT LIGSLAADYG
     FPDVGHLYKL EVGAPYLRVD GKTGDIFTTE TSIDREGLRE CQNQLPGDPC ILEFEVSITD
     LVQNGSPRLL EGQIEVQDIN DNTPNFASPV
//